Families - ACS

Acyl-CoA synthases form thioester bonds, mainly between acyl chains and coenzyme A (CoA), but also among other substrates.

Family	Names of enzymes and genes present
ACS1	AMP-binding protein Long-chain-fatty-acid-CoA ligase FadD 4-chlorobenzoate-CoA ligase Acetyl-CoA synthetase acsA Benzoate-CoA ligase Short-chain-fatty-acid-CoA ligase fadK Long-chain-fatty-acid-ACP ligase mbtM 4-hydroxybenzoyl-CoA synthetase 2-succinylbenzoate-CoA ligase 3-hydroxybenzoyl-CoA ligase Medium-chain fatty acid-CoA ligase 4-coumarate-CoA ligase 4CLL1, 4CLL2, 4CLL5, 4CLL6, 4CLL7, 4CLL8, 4CLL9, 4CL1, 4CL2, 4CL3, 4CL4 Acetoacyl-CoA synthetase Long-chain-acyl-CoA synthetase LACS1, LACS2, LACS3, LASC4, LACS5, LACS6, LACS7, LACS8, LACS9, Acyl-CoA synthetase mitochondrial ACSM1, ACSM2, ACSM3, ACSM4, ACSM5 Fatty acyl-CoA synthetase A, fcsA Acetyl-CoA synthetase, ACSS1, ACSS2 Acyl-CoA synthase family member, ACSF2, ACSF3
ACS2	BioW 6-carboxyhexanoate-CoA ligase Pimeloyl-CoA synthase
ACS3	Citrate lyase ligase citC [Citrate (pro-3S)-lyase]-ligase
ACS4	Phenylacetate-CoA ligase paaK
ACS5	Succinyl-CoA synthetase alpha chain (sucD) Succinyl-CoA ligase subunit beta (sucC)

ThYme: Thioester-active Enzymes