ThYme: Thioester-active Enzymes

Families - KS

Ketoacyl synthases condense the acyl-X chain with a carboxylated acyl-X chain, where X is either CoA or ACP. In fatty acid synthesis this step adds two carbon atoms to the growing fatty acid chain.

Family Names of enzymes and genes present
KS1

Beta-ketoacyl-ACP synthase III
FabH
Bibenzyl synthase
 

KS2

Fatty Acid Elongation (FAE)
Fiddlehead (FDH)
3-ketoacyl-CoA synthase (KCS)
KCS1-KCS5, KCS7-KCS10 KCS14-21
Very long-chain fatty acid condensing enzyme (VLCFA)

KS3

KS domain of polyketide synthases (PKSs)
KS domain of fatty acid synthases (FASs)
3-oxoacyl-ACP synthase I (fabB)
3-oxoacyl-ACP synthase II (fabF)
Beta-ketoacyl-ACP synthase 1 (kasA)
Beta-ketoacyl-ACP synthase 2 (kasB)
Polyketide synthase (pks)
pksF, pksJ, pksN, pksM, pksR, pksL
pks2, pks5
Mycocerosic acid synthase
6-methylsalicylic acid synthase

KS4

Chalcone synthases (CHS)
Stilbene synthases (STS)
2-pyrone synthases 
Naringenin-chalcone synthases
Trihydroxybenzophenone synthases
Stilbenecarboxylate synthases
Pinosylvin synthases
Benzalacetone synthases
Acridone synthases
 

KS5

Elongation of very long chain fatty acids (ELOVL)
ELOVL1-ELOVL7
Elongation of fatty acids protein(ELO)
ELO1-ELO6