ThYme: Thioester-active Enzymes

Family ACP10

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Names of enzymes and/or genes present

ACP part of PKS and NRPS

EC numbers
Catalytic residues
Notes
Numbers [P] (Evidence at Protein Level) = 65
[T] (Evidence at Transcript Level) = 2
PDBs = 11
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Rifamycin polyketide synthase, type 1 {ECO:0000313|EMBL:CAA11039.1} Amycolatopsis mediterranei (Nocardia mediterranei). AAC01714.1
ADJ42441.1
AEK39127.1
AFO74155.1
AGT81284.1
CAA11039.1
KDO09650.1
KDU86476.1
WP_013222551.1
YP_003762843.1
D8HZ86
G0FS59
O54593 [P]

Phenylalanine racemase [ATP-hydrolyzing] 5.1.1.11
Aneurinibacillus migulanus (Bacillus migulanus). AAA58718.1
CAA33603.1

P0C061 [P]

TubC protein {ECO:0000313|EMBL:CAF05648.1} Angiococcus disciformis. CAF05648.1

Q5ZPA9 [P]

ZmaA {ECO:0000313|EMBL:ACM79805.1} Bacillus cereus. ACM79805.1

C0JRE5 [P]

Polyketide synthase PksM Bacillus subtilis (strain 168). AFQ57653.1
AGG61091.1
AHA77748.1
AIC40137.1
AIC44369.1
AIY93021.1
AIY97331.1
AJE94401.1
BAM57942.1
CAA84505.1
CAB13603.3
CEI56903.1
EME07005.1
KFH32912.1
KFH33808.1
KIX82977.1
NP_389601.3
WP_003245093.1
A0A0A1M3Q5
P40872 [P]
P40872.4

Polyketide synthase PksL Bacillus subtilis (strain 168). AAA85145.1
AFQ57652.1
AGG61090.1
CAA78479.1
CAA84504.1
CAB13602.3
NP_389600.3
WP_010886513.1
Q05470 [P]
Q05470.3

Polyketide synthase PksN 2.3.1.-
Bacillus subtilis (strain 168). AGG61092.1
CAB13604.3
NP_389602.3
WP_010886514.1
O31782 [P]
O31782.3

Surfactin synthase subunit 3 Bacillus subtilis (strain 168). AFQ56286.1
AGG59694.1
AHA76317.1
AIC38727.1
AIC42959.1
AIY91633.1
AIY95942.1
AJE93032.1
BAA08985.1
BAM49281.1
BAM56551.1
CAA49818.1
CAB12145.2
CEI55470.1
EHA29021.1
EME05085.1
KFH30027.1
KFH34847.1
KIX81192.1
NP_388233.2
WP_003234570.1
A0A0A1M957
G4F045
L8ACT2
Q08787 [P]
Q08787.2
2VSQ
Tyrosine activase 2 2.3.1.-
Bacillus subtilis (strain 168). AFQ57767.1
AGG61207.1
CAA84363.1
CAB13714.2
CEI57025.1
CEJ77450.1
KFH29717.1
KFH36139.1
NP_389713.2
WP_009967354.1
A0A0A1LXS8
A0A0A1STI0
P94459 [P]
P94459.2

Leucine activase Bacillus subtilis (strain 168).

P39135 [P]
Q08788 [P]
2K2Q
4MRT
Surfactin synthetase {ECO:0000313|EMBL:AEW31037.1} Bacillus subtilis subsp. subtilis. AAA22815.1
AAA22816.1
AEW31037.1
AGG59691.1
AHA76315.1
AIC38725.1
AIC42957.1
AIY91631.1
AIY95940.1
AJE93030.1
BAA02522.1
BAA08982.1
BAA21034.1
BAM49279.1
BAM56549.1
CAA49816.1
CAB12142.2
CEI55468.1
EXF52073.1
KFH30025.1
KFH34845.1
NP_388230.2
WP_010886402.1
A0A0A1LT55
G9LQ66
L8ABH8
P27206 [P]
P27206.4

Surfactin synthetase {ECO:0000313|EMBL:AEW31038.1} Bacillus subtilis subsp. subtilis. AEW31038.1
AFQ56284.1
AGG59692.1
AHA76316.1
AIC38726.1
AIC42958.1
AIY91632.1
AIY95941.1
AJE93031.1
BAA02523.1
BAA08983.1
BAM49280.1
BAM56550.1
CAA46678.1
CAA49817.1
CAA51223.1
CAB12143.2
CEI55469.1
KFH30026.1
KFH34846.1
NP_388231.2
WP_010886403.1
G9LQ67
L8ACC1
Q04747 [P]
Q04747.3
Q45675

Plipastatin synthase subunit E {ECO:0000313|EMBL:CEI57024.1} 2.3.1.-
Bacillus subtilis. AFQ57766.1
AGG61206.1
AHA77871.1
AIC40255.1
AIC44487.1
AIY93142.1
AIY97450.1
AJE94522.1
BAM52485.1
BAM58061.1
CAA74213.1
CAB13713.1
CEI57024.1
KIX83097.1
NP_389712.1
WP_009967353.1
WP_010886522.1
A0A0A1MD49
L8ALS6
O31827 [P]
O31827.1

Dimodular nonribosomal peptide synthase {ECO:0000313|EMBL:CEI58446.1} 2.7.7.- {ECO:0000313|EMBL:CEI58446.1}
Bacillus subtilis. AAC44634.1
AAD56240.1
AFQ59041.1
AGG62601.1
AHA79122.1
AIC41664.1
AIC45895.1
AIY94515.1
AIY98825.1
AJE95895.1
BAM55266.1
BAM59279.1
CAB15186.3
CEI58446.1
KFH30910.1
KFH32730.1
KIX81680.1
NP_391076.3
WP_009968094.1
A0A0A1M8B3
L8AUM1
P45745 [P]
P45745.4

Polyketide synthase PksR {ECO:0000313|EMBL:CEI56906.1} 2.3.1.-
Bacillus subtilis. AFQ57654.1
AGG61093.1
AHA77749.1
AIC40139.1
AIC44371.1
AIY93023.1
AIY97332.1
AJE94403.1
BAM57945.1
CAB13606.2
CEI56906.1
EME07445.1
KFH32910.1
KFH33806.1
KIX82979.1
NP_389604.2
WP_003245624.1
A0A0A1MEV4
O31784 [P]
O31784.2

Polyketide synthase PksJ {ECO:0000313|EMBL:CEI56901.1} Bacillus subtilis. AAA85143.1
AAA85144.1
AGG61089.1
AHA77746.1
AIC40135.1
AIC44367.1
AIY93019.1
AIY97329.1
AJE94399.1
BAM57940.1
CAB13589.3
CEI56901.1
EME07387.1
KFH32914.1
KFH33810.1
KIX82975.1
NP_389598.3
WP_003245563.1
A0A0A1MEU5
P40806 [P]
P40806.3

Plipastatin synthase subunit C {ECO:0000313|EMBL:CEI57026.1} 2.3.1.-
Bacillus subtilis. AFQ57768.1
AGG61208.1
AIY93144.1
AIY97452.1
AJE94524.1
CAA84362.1
CAB13715.1
CEI57026.1
KFH36138.1
NP_389714.1
WP_009967356.1
A0A0A1MFA4
P39847 [P]
P39847.2

Plipastatin synthase subunit A {ECO:0000313|EMBL:CEI57028.1} 2.3.1.-
Bacillus subtilis. AGG61210.1
AHA77874.1
AIC40258.1
AIC44490.1
AIY93146.1
AIY97454.1
AJE94526.1
CAA84360.1
CAB13717.2
CEI57028.1
KFH36136.1
KFH37331.1
NP_389716.2
WP_009967358.1
WP_010886523.1
A0A0A1M456
P39845 [P]
P39845.2

Plipastatin synthase subunit B {ECO:0000313|EMBL:CEI57027.1} 2.3.1.-
Bacillus subtilis. AFQ57769.1
AGG61209.1
AHA77873.1
AIC40257.1
AIC44489.1
AIY93145.1
AIY97453.1
AJE94525.1
CAA84361.1
CAB13716.1
CEI57027.1
EME04831.1
KFH36137.1
KFH37332.1
KIX80148.1
NP_389715.1
WP_003247155.1
A0A0A1MDK5
P39846 [P]
P39846.1

Leucine activase Brevibacillus brevis (Bacillus brevis). BAA00778.1
BAA06146.1

P0C064 [P]
P0C064.2

Phenylalanine racemase [ATP-hydrolyzing] 5.1.1.11
Brevibacillus parabrevis. AAA22876.1
AAC45928.1
CAA31623.1

P09095 [P]

Glycine activase Brevibacillus parabrevis. CAD92849.1

Q70LM7 [P]

Leucine activase Brevibacillus parabrevis. AAC45930.1

O30409 [P]
1DNY
2GDW
2GDX
2GDY
2JGP
2MD9
Valine racemase [ATP-hydrolyzing] 5.1.1.-
Brevibacillus parabrevis. CAD92850.1

Q70LM6 [P]
Q70LM6.1

Linear gramicidin--PCP reductase 1.-.-.-
5.1.1.-
Brevibacillus parabrevis. CAD92852.1

Q70LM4 [P]
Q70LM4.1

RhiE protein {ECO:0000313|EMBL:CAL69893.1} Burkholderia rhizoxinica. CAL69893.1

A1KQS1 [P]

Tyrosine activase Chondromyces crocatus. CAJ46692.1

Q0VZ70 [P]
Q0VZ70.1

CurF {ECO:0000313|EMBL:AAT70101.1} Lyngbya majuscula. AAT70101.1

Q6DNE7 [P]

CurH {ECO:0000313|EMBL:AAT70103.1} Lyngbya majuscula. AAT70103.1

Q6DNE5 [P]

Zn-dependent oxidoreductase/polyketide synthase module {ECO:0000313|EMBL:EGJ28347.1} Moorea producens 3L. AEE88282.1
EGJ28347.1

F4Y428 [P]

Beta-ketoacyl-acyl-carrier-protein synthase I 2.3.1.41
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97). AET20219.1
AGE68946.1
BAH27226.1
CAL72942.1
CDO44223.1
KAN92861.1
KEC51282.1
KEY08631.1
KFW37558.1
NP_856601.1
A1KMS6
C1AG47
Q7TXM0 [P]
Q7TXM0.1

Beta-ketoacyl-acyl-carrier-protein synthase I 2.3.1.41
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97). CDO44224.1
CEJ36581.1
CEJ39146.1
KAO04562.1
KBG55950.1
KEY08632.1
KEY08893.1
KEY09330.1
NP_856602.1
Q7TXL9 [P]
Q7TXL9.1

Probable polyketide synthase pks1 {ECO:0000313|EMBL:CCC65545.1} 2.3.1.41
Mycobacterium bovis BCG str. Moreau RDJ. AET20234.1
AGE68963.1
BAH27241.1
CAL72957.1
CCC65545.1
CDO44238.1
ESK74491.1
KEC51266.1
KEY07880.1
KEY08646.1
KEY08907.1
NP_856616.1
WP_010950804.1
A1KMU1
C1AG62
F9UXI5
Q7TXK8 [P]
Q7TXK8.1

p-hydroxybenzoyl-AMP ligase FadD22 {ECO:0000313|EMBL:KBN11067.1} 6.2.1.-
6.2.1.- {ECO:0000313|EMBL:KFC54544.1}
6.2.1.25 {ECO:0000313|EMBL:KDA15165.1}
Mycobacterium bovis. AIR48165.1
CCC65546.1
CDO44239.1
NP_856617.1
A0A083VV02
F9UXI6
Q7TXK7 [P]

Beta-ketoacyl-acyl-carrier-protein synthase I 2.3.1.41
Mycobacterium marinum (strain ATCC BAA-535 / M). ACC40211.1
WP_012393570.1
YP_001850066.1
B2HIL7 [P]
B2HIL7.1

p-hydroxybenzoic acid-AMP synthetase 6.2.1.-
Mycobacterium marinum (strain ATCC BAA-535 / M). ACC40210.1
WP_012393569.1
YP_001850065.1
B2HIL6 [P]
B2HIL6.1

Beta-ketoacyl-acyl-carrier-protein synthase I 2.3.1.41
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). ABQ74738.1
AFN50914.1
CCP45734.1
KBU78877.1
KCN97006.1
NP_217447.1
WP_010886158.1
YP_006516385.1
A5U6T8
I6XFQ0
P9WQE7 [P]
P9WQE7.1

Polyketide synthase Pks1 {ECO:0000313|EMBL:KBN11065.1} Mycobacterium tuberculosis OFXR-28. ABQ74754.1
ABR07287.1
AEJ51507.1
AEN01410.1
AFN50928.1
AHJ56188.1
AIB49645.1
AJF04308.1
BAL67008.1
BAQ07093.1
CCG12829.1
CCP45750.1
EGB27591.1
KAK92702.1
KAK98929.1
KAL11218.1
KAL15713.1
KAL20073.1
KAL22028.1
KAL26469.1
KAL31633.1
KAL36645.1
KAL39254.1
KAL41921.1
KAL45930.1
KAL51309.1
KAL52396.1
KAL58183.1
KAL64073.1
KAL65080.1
KAL75233.1
KAL77652.1
KAL82766.1
KAL85180.1
KAL90902.1
KAL95280.1
KAM06553.1
KAM19283.1
KAM24908.1
KAM26306.1
KAM29105.1
KAM34016.1
KAM37388.1
KAM38168.1
KAM48246.1
KAM55381.1
KAM60877.1
KAM65314.1
KAM67411.1
KAM71336.1
KAM78486.1
KAM79852.1
KAM83354.1
KAM89014.1
KAM91519.1
KAM94887.1
KAN00915.1
KAN03801.1
KAN06220.1
KAN09122.1
KAN17355.1
KAN18847.1
KAN22639.1
KAN29325.1
KAN32715.1
KAN33676.1
KAN42042.1
KAN43110.1
KAN47058.1
KAN51467.1
KAN58439.1
KAN60030.1
KAN65503.1
KAN68938.1
KAN72901.1
KAN73718.1
KAN78582.1
KAN84665.1
KAN88858.1
KAN97186.1
KAO01239.1
KAO10938.1
KAO18659.1
KAO20838.1
KAO22942.1
KAO35268.1
KAO47640.1
KAO55233.1
KAO59620.1
KAO65612.1
KAO66351.1
KAO71654.1
KAO75103.1
KAO79927.1
KAO82956.1
KAO87950.1
KAO90521.1
KAP00327.1
KAP02326.1
KAP09354.1
KAP12128.1
KAP15459.1
KAP19226.1
KAP20758.1
KAP27624.1
KAP32131.1
KAP36039.1
KAP39497.1
KAP47651.1
KAP50189.1
KAP51742.1
KAP58780.1
KAP64208.1
KAP73121.1
KAP75681.1
KAP80830.1
KAP84582.1
KAP87129.1
KAP90610.1
KAP97445.1
KAP99352.1
KAQ05434.1
KAQ15038.1
KAQ21968.1
KAQ27800.1
KAQ30808.1
KAQ34636.1
KAQ42337.1
KAQ45340.1
KAQ50453.1
KAQ59486.1
KAQ59581.1
KAQ61529.1
KAQ64800.1
KAQ67814.1
KAQ73936.1
KAQ80767.1
KAQ81696.1
KAQ86680.1
KAQ91019.1
KAQ93571.1
KAQ98169.1
KAR03054.1
KAR06603.1
KAR11664.1
KAR16180.1
KAR23991.1
KAR25484.1
KAR32813.1
KAR36150.1
KAR42377.1
KAR47793.1
KAR50329.1
KAR59592.1
KAR62602.1
KAR71969.1
KAR75802.1
KAR75902.1
KAR84030.1
KAR87074.1
KAR87556.1
KAS00192.1
KAS09819.1
KAS10694.1
KAS15407.1
KAS22691.1
KAS25131.1
KAS33390.1
KAS42341.1
KAS44998.1
KAS51002.1
KAS56334.1
KAS63091.1
KAS64113.1
KAS74587.1
KAS80190.1
KAS83868.1
KAS88844.1
KAT03014.1
KAT06048.1
KAT15957.1
KAT20763.1
KAT21863.1
KAT28939.1
KAT29251.1
KAT33833.1
KAT38210.1
KAT47574.1
KAT47784.1
KAT49642.1
KAT50159.1
KAT58819.1
KAT71837.1
KAT73581.1
KAT74710.1
KAT83907.1
KAT86907.1
KAT89963.1
KAT95284.1
KAU02224.1
KAU08104.1
KAU15750.1
KAU17567.1
KAU19866.1
KAU33756.1
KAU35275.1
KAU37796.1
KAU45723.1
KAU48503.1
KAU55300.1
KAU56120.1
KAU58274.1
KAU66348.1
KAU71775.1
KAU78741.1
KAU85454.1
KAU85646.1
KAU91821.1
KAU94621.1
KAV03053.1
KAV10232.1
KAV11120.1
KAV16662.1
KAV28681.1
KAV30768.1
KAV34102.1
KAV37735.1
KAV42026.1
KAV50907.1
KAV54246.1
KAV58937.1
KAV66439.1
KAV75358.1
KAV80756.1
KAV84003.1
KAV86575.1
KAV91944.1
KAW03789.1
KAW07891.1
KAW14969.1
KAW15646.1
KAW26249.1
KAW38967.1
KAW39907.1
KAW45851.1
KAW50998.1
KAW53384.1
KAW61186.1
KAW65741.1
KAW70970.1
KAW78134.1
KAW84661.1
KAW87422.1
KAW92128.1
KAX65185.1
KAY15905.1
KAY46443.1
KAY58489.1
KAY71160.1
KAZ04541.1
KAZ24184.1
KAZ45238.1
KBA11836.1
KBA43525.1
KBA53049.1
KBA60288.1
KBA73587.1
KBA80308.1
KBA89633.1
KBA96700.1
KBB09293.1
KBB12479.1
KBB15818.1
KBB23953.1
KBB28642.1
KBB35548.1
KBB45187.1
KBB47067.1
KBB60279.1
KBB70052.1
KBB72050.1
KBB88916.1
KBC21654.1
KBC33145.1
KBC36441.1
KBC39617.1
KBC56012.1
KBC57352.1
KBC63127.1
KBC91681.1
KBD07795.1
KBD27564.1
KBD43627.1
KBD47176.1
KBD67278.1
KBD75101.1
KBD83774.1
KBD94096.1
KBD98323.1
KBE02548.1
KBE06850.1
KBE21295.1
KBE26772.1
KBE31274.1
KBE47109.1
KBE51075.1
KBE59352.1
KBF33479.1
KBF50212.1
KBF61296.1
KBF69911.1
KBF77427.1
KBG07655.1
KBG17171.1
KBG21689.1
KBG40756.1
KBG70410.1
KBG76044.1
KBG80267.1
KBG86173.1
KBH29657.1
KBH31175.1
KBH45001.1
KBH99728.1
KBH99873.1
KBI09673.1
KBI33967.1
KBI38440.1
KBI48736.1
KBI70093.1
KBJ00172.1
KBJ25141.1
KBJ29862.1
KBJ33960.1
KBJ50116.1
KBJ64025.1
KBJ66737.1
KBJ67885.1
KBJ76211.1
KBJ90040.1
KBJ93118.1
KBJ97972.1
KBK05216.1
KBK06093.1
KBK10576.1
KBK14390.1
KBK20874.1
KBK29229.1
KBK29439.1
KBK38941.1
KBK39309.1
KBK41517.1
KBK44934.1
KBK45695.1
KBK59015.1
KBK59638.1
KBK69037.1
KBK69343.1
KBK75232.1
KBK76391.1
KBK83841.1
KBK87179.1
KBK92572.1
KBK98718.1
KBL02188.1
KBL09132.1
KBL14251.1
KBL15660.1
KBL16354.1
KBL21097.1
KBL26707.1
KBL30931.1
KBL42190.1
KBL44213.1
KBL47604.1
KBL50839.1
KBL51114.1
KBL57363.1
KBL61692.1
KBL72769.1
KBL75594.1
KBL79441.1
KBL86446.1
KBL90354.1
KBL92786.1
KBL98346.1
KBM02759.1
KBM10666.1
KBM11675.1
KBM16911.1
KBM25000.1
KBM29197.1
KBM30942.1
KBM37792.1
KBM40384.1
KBM45057.1
KBM46526.1
KBM48592.1
KBM61304.1
KBM64378.1
KBM66388.1
KBM70668.1
KBM76275.1
KBM81059.1
KBM85366.1
KBM86792.1
KBM91828.1
KBM93544.1
KBN02311.1
KBN03210.1
KBN09870.1
KBN11065.1
KBN19655.1
KBN25752.1
KBN27317.1
KBN29874.1
KBN35782.1
KBO36267.1
KBO39707.1
KBO40094.1
KBO61613.1
KBO89326.1
KBO97272.1
KBP36565.1
KBP62664.1
KBP64617.1
KBP67201.1
KBP71891.1
KBP72090.1
KBP79398.1
KBP84227.1
KBP84330.1
KBP88750.1
KBP92614.1
KBP98081.1
KBQ03047.1
KBQ07060.1
KBQ12447.1
KBQ17270.1
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NP_217462.1
WP_003917711.1
YP_006516399.1
A0A047RSJ3
A0A047RVZ5
A0A056EME9
A0A056FRB0
A5U6V4
A5WRJ8
H8EWC9
I6Y235
P96285 [P]
P96285.4

Phenolpthiocerol synthesis type-I polyketide synthase PpsB {ECO:0000313|EMBL:KBN11052.1} 2.3.1.41
Mycobacterium tuberculosis OFXR-28. AAK47329.1
ABQ74739.1
ACT24086.1
AEN01395.1
AFN50915.1
AGM01523.1
AHJ43731.1
AHJ47880.1
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CCG12814.1
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CDM11328.1
EAY61090.1
EBA43127.2
EFD54748.1
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EFI31489.1
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EFP14878.1
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KEB69567.1
KEB72544.1
KEB77920.1
KEB81406.1
KEB82773.1
KEB85373.1
KEB94168.1
KEB96071.1
KEC00155.1
KEC04633.1
KEC10203.1
KEC14493.1
KEC17615.1
KEC20612.1
KEC24814.1
KEC29568.1
KEC38261.1
KEC38358.1
KEC43217.1
KEC44890.1
KEC91442.1
KED06460.1
NP_217448.1
NP_337515.1
WP_003899547.1
YP_006516386.1
A0A045JEK8
A0A047RR62
A0A047RUR1
A0A056EQB8
A0A056FT59
A0A0B6TED2
A2VLQ9
A5U6T9
C6DWC2
I6YER4
P9WQE4
P9WQE4.1
P9WQE5 [P]
P9WQE5.1

p-hydroxybenzoyl-AMP ligase FadD22 {ECO:0000313|EMBL:KBN11067.1} 6.2.1.-
6.2.1.- {ECO:0000313|EMBL:KFC54544.1}
6.2.1.25 {ECO:0000313|EMBL:KDA15165.1}
Mycobacterium tuberculosis OFXR-28. AAK47347.1
ABQ74756.1
ABR07289.1
ACT24068.1
AEB03160.1
AEJ47898.1
AEJ51509.1
AEN01412.1
AET20235.1
AFE17754.1
AFM48408.1
AFN50930.1
AGE68964.1
AGJ69057.1
AGL28389.1
AGM01540.1
AHJ43747.1
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AHM08704.1
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AIH18161.1
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CAL72958.1
CCE38406.1
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CDM11345.1
CEJ33393.1
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EGB27593.1
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KCD53648.1
KCD57125.1
KCD62409.1
KCD66940.1
KCD68122.1
KCD74264.1
KCD75885.1
KCD84918.1
KCD87181.1
KCD89397.1
KCD94325.1
KCE04140.1
KCE05895.1
KCE10380.1
KCE14064.1
KCE17496.1
KCE21146.1
KCE26355.1
KCE28128.1
KCE34583.1
KCE35348.1
KCE43005.1
KCE46352.1
KCE48389.1
KCE55133.1
KCE63810.1
KCE63966.1
KCE70811.1
KCE78040.1
KCE80182.1
KCE86505.1
KCE88884.1
KCE94073.1
KCE96862.1
KCF02044.1
KCF06837.1
KCF09507.1
KCF15138.1
KCF15510.1
KCF22977.1
KCF23968.1
KCF40495.1
KCF44431.1
KCF47195.1
KCF51122.1
KCF55908.1
KCF56293.1
KCF62218.1
KCF68406.1
KCF72402.1
KCF75324.1
KCF77315.1
KCF83506.1
KCF84953.1
KCF90542.1
KCF97166.1
KCG02611.1
KCG03771.1
KCG10866.1
KCG12867.1
KCG20141.1
KCG21571.1
KCG29515.1
KCG31403.1
KCG35723.1
KCG37203.1
KCG42597.1
KCG45294.1
KCG49341.1
KCG57123.1
KCG60367.1
KCG65016.1
KCG66265.1
KCG70299.1
KCG71602.1
KCG77591.1
KCG80889.1
KCG87405.1
KCG87617.1
KCG93179.1
KCG95635.1
KCH02493.1
KCH08377.1
KCH11481.1
KCH12113.1
KCH17893.1
KCH22125.1
KCH27119.1
KCH28740.1
KCH34705.1
KCH35231.1
KCH43483.1
KCH47542.1
KCH54978.1
KCH57646.1
KCH61079.1
KCH65828.1
KCH73674.1
KCH75697.1
KCH82759.1
KCH88925.1
KCH94705.1
KCH95977.1
KCH98014.1
KCI00036.1
KCI06780.1
KCI07691.1
KCI12705.1
KCI21097.1
KCI23300.1
KCI28418.1
KCI28633.1
KCI33634.1
KCI35541.1
KCI40817.1
KCI47002.1
KCI51251.1
KCI55913.1
KCI58319.1
KCI64332.1
KCI66531.1
KCI70964.1
KCI76164.1
KCI76375.1
KCI81427.1
KCI86471.1
KCI88616.1
KCI94174.1
KCI99785.1
KCJ02486.1
KCJ06390.1
KCJ11215.1
KCJ11697.1
KCJ19828.1
KCJ27182.1
KCJ29004.1
KCJ29472.1
KCJ33362.1
KCJ38804.1
KCJ42719.1
KCJ49199.1
KCJ51257.1
KCJ55215.1
KCJ57557.1
KCJ61737.1
KCJ68458.1
KCJ71609.1
KCJ74025.1
KCJ76382.1
KCJ82804.1
KCJ87434.1
KCJ90716.1
KCJ92134.1
KCJ96559.1
KCK04165.1
KCK08073.1
KCK11783.1
KCK17512.1
KCK22439.1
KCK22650.1
KCK27024.1
KCK28776.1
KCK34833.1
KCK38946.1
KCK42234.1
KCK44067.1
KCK49749.1
KCK55219.1
KCK55928.1
KCK64675.1
KCK67718.1
KCK70065.1
KCK75983.1
KCK77210.1
KCK84582.1
KCK85106.1
KCK93038.1
KCK93648.1
KCL00569.1
KCL03735.1
KCL05903.1
KCL12144.1
KCL13514.1
KCL20687.1
KCL24431.1
KCL26655.1
KCL29308.1
KCL32592.1
KCL40423.1
KCL42085.1
KCL46667.1
KCL47527.1
KCL53110.1
KCL54683.1
KCL62072.1
KCL67815.1
KCL70112.1
KCL75484.1
KCL78686.1
KCL86293.1
KCL88480.1
KCL90354.1
KCL92761.1
KCL98308.1
KCM03107.1
KCM06481.1
KCM10646.1
KCM16100.1
KCM18256.1
KCM19762.1
KCM26315.1
KCM28869.1
KCM34046.1
KCM34773.1
KCM42524.1
KCM50828.1
KCM50966.1
KCM54869.1
KCM57859.1
KCM63880.1
KCM66091.1
KCM70146.1
KCM79115.1
KCM79318.1
KCM86545.1
KCM87733.1
KCM94698.1
KCM95797.1
KCN02493.1
KCN05399.1
KCN12101.1
KCN13673.1
KCN18601.1
KCN18741.1
KCN26627.1
KCN30801.1
KCN31206.1
KCN36073.1
KCN42255.1
KCN46362.1
KCN47471.1
KCN50783.1
KCN54484.1
KCN61968.1
KCN62108.1
KCN68355.1
KCN69148.1
KCN76475.1
KCN77295.1
KCN84791.1
KCN86144.1
KCN91849.1
KCN97022.1
KCO01978.1
KCO03888.1
KCO08987.1
KCO12456.1
KCO16993.1
KCO19993.1
KCO22421.1
KCO28873.1
KCO30111.1
KCO37769.1
KCO38043.1
KCO43638.1
KCO48920.1
KCO51386.1
KCO56554.1
KCO59493.1
KCO62636.1
KCO71007.1
KCO75887.1
KCO77531.1
KCO87133.1
KCO89664.1
KCO94942.1
KCO99838.1
KCP09358.1
KCP11412.1
KCP15347.1
KCP18558.1
KCP23079.1
KCP27107.1
KCP31820.1
KCP43892.1
KCP51470.1
KCP54097.1
KCP55676.1
KCP60122.1
KCP62531.1
KCP67110.1
KCP71748.1
KCP78624.1
KCP83767.1
KCP85370.1
KCP92036.1
KCP98952.1
KCP99524.1
KCQ01432.1
KCQ09731.1
KCQ12566.1
KCQ15398.1
KCQ18012.1
KCQ24162.1
KCQ25682.1
KCQ31152.1
KCQ38443.1
KCQ41604.1
KCQ42982.1
KCQ51420.1
KCQ55637.1
KCQ68495.1
KCQ71383.1
KCQ75193.1
KCQ80722.1
KCQ87937.1
KCQ89175.1
KCQ96758.1
KCQ99439.1
KCR03632.1
KCR05367.1
KCR11723.1
KCR13481.1
KCR17595.1
KCR22019.1
KCR27753.1
KCR28867.1
KCR35158.1
KCR39247.1
KCR42297.1
KCR47556.1
KCR50435.1
KCR57370.1
KCR61872.1
KCR62499.1
KCR65766.1
KCR71440.1
KCR78924.1
KCR82924.1
KCR85958.1
KCR87964.1
KCR89435.1
KCR94504.1
KCR95177.1
KCS00272.1
KCS06668.1
KCS13192.1
KCS13349.1
KCS19243.1
KCS25326.1
KCS29210.1
KCS30440.1
KCS33306.1
KCS40212.1
KCS45015.1
KCS45792.1
KCS49701.1
KCS57698.1
KCS60643.1
KCS66894.1
KCS68390.1
KCS73740.1
KCS74518.1
KCS80554.1
KCS81129.1
KCS87787.1
KCS88506.1
KCS95810.1
KCS96859.1
KCT02118.1
KCT07522.1
KCT11639.1
KCT15324.1
KCT17859.1
KCT24239.1
KCT24656.1
KCT34135.1
KCT34847.1
KCT37581.1
KCT44482.1
KCT45295.1
KCT50447.1
KCT52244.1
KCT55542.1
KCT66116.1
KCT68720.1
KCT72066.1
KCT74452.1
KCT79952.1
KCT82663.1
KCT87707.1
KCT89406.1
KCT95062.1
KCT95523.1
KCU03606.1
KCU07499.1
KCU08600.1
KCU15602.1
KCU17810.1
KCU24672.1
KCU25237.1
KCU33158.1
KCU35217.1
KCU37602.1
KCU44469.1
KCU44888.1
KCU53105.1
KCU56175.1
KCU60678.1
KCU65727.1
KCU69361.1
KCU71687.1
KCU77929.1
KCU82167.1
KCU84966.1
KCU85911.1
KDA15165.1
KEA68712.1
KEA79147.1
KEA86063.1
KEA89315.1
KEA92236.1
KEA95539.1
KEB01574.1
KEB03739.1
KEB09136.1
KEB13151.1
KEB15102.1
KEB20078.1
KEB20701.1
KEB26989.1
KEB41489.1
KEB44773.1
KEB53215.1
KEB58567.1
KEB59493.1
KEB69581.1
KEB72558.1
KEB74520.1
KEB81391.1
KEB82788.1
KEB85388.1
KEB94183.1
KEB96086.1
KEC00170.1
KEC04648.1
KEC10218.1
KEC14508.1
KEC17629.1
KEC20627.1
KEC24829.1
KEC29582.1
KEC32169.1
KEC38275.1
KEC38372.1
KEC43231.1
KEC44905.1
KEC51265.1
KEC91457.1
KED06474.1
KEP58731.1
KEY07881.1
KEY08647.1
KEY08908.1
KFC54544.1
KFE92561.1
KFW14387.1
KFW15810.1
KFW16476.1
KFW25812.1
KFW27159.1
KFW29579.1
KFW37574.1
KFW39874.1
KFW40878.1
KFW50546.1
KFW50956.1
KFW52395.1
KHG67516.1
KHS01549.1
KIN22550.1
KIU59697.1
KIX88521.1
NP_217464.1
NP_337533.1
WP_003414884.1
YP_006516401.1
YP_007962815.1
A0A045HFC2
A0A047RR77
A0A047RUS5
A0A056EQD5
A0A056FQZ9
A0A0B6SZD8
A1KMU2
A2VLS2
A5U6V6
A5WRK0
C1AG63
C6DWA4
H8EWD1
I6YES5
P9WQ60
P9WQ60.1
P9WQ61 [P]
P9WQ61.1
Q7TXK7.1
R4M9P8

ORF 2 2.3.1.94
Saccharopolyspora erythraea (Streptomyces erythraeus). AAA26494.1
CAA44448.1

Q03132 [P]
Q03132.3

ORF 3 2.3.1.94
Saccharopolyspora erythraea (Streptomyces erythraeus). AAA26495.1
CAA39583.1
CAA44449.1

Q03133 [P]
Q03133.4

ORF 1 2.3.1.94
Saccharopolyspora erythraea (Streptomyces erythraeus). AAA26493.2
AAA26504.1

Q03131 [P]
Q03131.1
2JU1
2JU2
Polyketide synthase extender modules 3-4 {ECO:0000313|EMBL:AAG23266.1} Saccharopolyspora spinosa. AAG23266.1

Q9ALM4 [P]

Polyketide synthase extender module 2 {ECO:0000313|EMBL:AAG23265.1} Saccharopolyspora spinosa. AAG23265.1

Q9ALM5 [P]

NRPS/PKS {ECO:0000313|EMBL:ABS90470.1} Streptomyces albus. ABS90470.1

B2WW42 [P]

Tylactone synthase starter module and modules 1 & 2 {ECO:0000313|EMBL:AAB66504.1} Streptomyces fradiae (Streptomyces roseoflavus). AAB66504.1

O33954 [P]

Novobiocin biosynthesis protein H 6.-.-.-
Streptomyces niveus (Streptomyces spheroides). AAF67501.2

Q9L9G0 [P]
Q9L9G0.2

AmphI {ECO:0000313|EMBL:AAK73501.1} Streptomyces nodosus. AAK73501.1

Q93NX9 [P]

AmphB {ECO:0000313|EMBL:AAK73513.1} Streptomyces nodosus. AAK73513.1

Q93NW7 [P]

Peptide synthetase {ECO:0000313|EMBL:AEA30273.1} Streptomyces sp. Acta 2897. AEA30273.1

F2YRY5 [P]

Tautomycetin biosynthetic PKS {ECO:0000313|EMBL:ABI94380.1} Streptomyces sp. CK4412. ABI94380.1

A4KCE5 [P]

Type I polyketide synthase PikAII {ECO:0000313|EMBL:AAC69330.1} Streptomyces venezuelae. AAC69330.1

Q9ZGI4 [P]

Type I polyketide synthase PikAIII {ECO:0000313|EMBL:AAC69331.1} Streptomyces venezuelae. AAC69331.1

Q9ZGI3 [P]

Type I polyketide synthase PikAIV {ECO:0000313|EMBL:AAC69332.1} Streptomyces venezuelae. AAC69332.1

Q9ZGI2 [P]

Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase 6.3.2.26
Acremonium chrysogenum (Cephalosporium acremonium).

P25464 [P]
P25464.1

Type I polyketide synthase {ECO:0000313|EMBL:EDP07994.1} Chlamydomonas reinhardtii (Chlamydomonas smithii). EDP07994.1
XP_001698501.1
A8HZR1 [P]

Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase 6.3.2.26
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans). AAA03914.1
CAA38631.1
CBF84349.1
EAA62968.1
XP_660225.1
P27742 [P]
P27742.2

S-adenosyl-L-methionine-dependent N-methyltransferase 2.1.1.-
6.3.2.-
Fusarium equiseti (Fusarium scirpi). CAA79245.2

Q00869 [P]
Q00869.2

Beauvericin synthetase {ECO:0000313|EMBL:AGC31490.1} Fusarium venenatum. AGC31490.1

L7TB23 [T]

Siderophore peptide synthase D 6.3.2.-
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus). EAL86624.1
XP_748662.1
Q4WF53 [T]
Q4WF53.1

Gliotoxin synthesis protein 6.3.2.-
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus). ABE60889.1
EAL88817.1
XP_750855.1
Q4WMJ7 [P]
Q4WMJ7.1

Nonribosomal peptide synthetase 1 6.3.2.-
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus). EAL90366.1
XP_752404.1
Q4WT66 [P]
Q4WT66.1

Alpha-aminoadipate reductase {ECO:0000256|PIRNR:PIRNR001617} 1.2.1.31
1.2.1.31 {ECO:0000256|PIRNR:PIRNR001617}
Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast). AAA34747.1
AJP89356.1
AJQ05851.1
AJQ06624.1
CAA46975.1
CAA51938.1
CAA55617.1
CAA85072.1
DAA07234.1
EIW12044.1
NP_009673.1
N1P6N2
P07702 [P]
P07702.2

Alpha-aminoadipate reductase 1.2.1.31
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). AAC15909.1
CAB88271.1
NP_594314.1
P40976 [P]
P40976.3

Hydroxamate-type ferrichrome siderophore peptide synthetase 6.-.-.-
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). CAB72227.1
NP_593102.1
Q9P7T1 [P]
Q9P7T1.1