ThYme: Thioester-active Enzymes

Family TE17

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Fold α/β-Hydrolase
Names of enzymes and/or genes present TE domain of polyketide synthase (PKS)
EC numbers 1. 3.1.2.14 (oleoyl-ACP hydrolase) thioesterase domain
2. PKS 2.3.1.94, 2.3.1.-
Catalytic residues Ser, His, Asp
Notes

1. Have activity for several polyketides
2. Part of large multimodular PKS.
 

Numbers [P] (Evidence at Protein Level) = 3
[T] (Evidence at Transcript Level) = 0
PDBs = 10
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
ORF 3 2.3.1.94
Saccharopolyspora erythraea (Streptomyces erythraeus). AAA26495.1
CAA39583.1
CAA44449.1

Q03133 [P]
Q03133.4
1KEZ
1MO2
Tautomycetin biosynthetic PKS {ECO:0000313|EMBL:ABI94380.1} Streptomyces sp. CK4412. ABI94380.1

A4KCE5 [P]
3LCR
Type I polyketide synthase PikAIV {ECO:0000313|EMBL:AAC69332.1} Streptomyces venezuelae. AAC69332.1

Q9ZGI2 [P]
1MN6
1MNA
1MNQ
2H7X
2H7Y
2HFJ
2HFK