ThYme: Thioester-active Enzymes

Family ER4

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Fold NAD(P)-binding Rossmann
Names of enzymes and/or genes present

Enoyl-ACP reductase
 

EC numbers

1.3.1.10 (Enoyl-ACP reductase)
 

Catalytic residues
Notes

1. ER domain of fatty acid synthase (FAS) and polyketide synthases (PKS)
2. Shares some sequences with KR4 (different domains)
 

Numbers [P] (Evidence at Protein Level) = 22
[T] (Evidence at Transcript Level) = 36
PDBs = 6
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Phenolpthiocerol synthesis type-I polyketide synthase PpsC {ECO:0000313|EMBL:KBN11053.1} 2.3.1.41
2.3.1.41 {ECO:0000313|EMBL:KFC55694.1}
Mycobacterium tuberculosis OFXR-28. ABQ74740.1
ABR07274.1
AEJ47883.1
AEJ51494.1
AET20221.1
AFN50916.1
AGE68948.1
AGJ69041.1
AGM01524.1
AHJ43732.1
AHJ47881.1
AHJ52025.1
AHJ56174.1
AHM08690.1
AID05991.1
AIH18148.1
AIH25729.1
AIH71574.1
AII91526.1
AII95442.1
AIQ05577.1
AJF04294.1
AJK62962.1
BAH27228.1
BAQ07076.1
CAL72944.1
CCE38390.1
CCP45736.1
CDM11329.1
EFD18759.1
EFD48524.1
EFD54749.1
EFD63064.1
EFI31490.1
EFP14879.1
EFP18400.1
EFP22548.1
EFP25891.1
EFP37519.1
EFP50104.1
EGE51481.1
EPZ66034.1
EQM19090.1
EQM20517.1
ESK74480.1
KAL08208.1
KAL15701.1
KAL20061.1
KAL26457.1
KAL31621.1
KAL36633.1
KAL39242.1
KAL41909.1
KAL45918.1
KAL51321.1
KAL52384.1
KAL58171.1
KAL64061.1
KAL65068.1
KAL70843.1
KAL75221.1
KAL82754.1
KAL90890.1
KAL95268.1
KAM01062.1
KAM03616.1
KAM06541.1
KAM24896.1
KAM26294.1
KAM34004.1
KAM38156.1
KAM48234.1
KAM51264.1
KAM65302.1
KAN00903.1
KAN06208.1
KAN22627.1
KAN27639.1
KAN43098.1
KAN47046.1
KAN54876.1
KAN88846.1
KAN92863.1
KAN97174.1
KAO01227.1
KAO06961.1
KAO20826.1
KAO27915.1
KAO32399.1
KAO39201.1
KAO42838.1
KAO51737.1
KAO55221.1
KAO66339.1
KAO79915.1
KAO82944.1
KAO87938.1
KAO90509.1
KAP00315.1
KAP19214.1
KAP27612.1
KAP32119.1
KAP42890.1
KAP68303.1
KAP75669.1
KAP97433.1
KAP99340.1
KAQ05616.1
KAQ12124.1
KAQ21956.1
KAQ27788.1
KAQ30796.1
KAQ34624.1
KAQ38427.1
KAQ50441.1
KAQ59474.1
KAQ81684.1
KAQ86668.1
KAR11652.1
KAR14785.1
KAR22653.1
KAR23979.1
KAR32801.1
KAR36138.1
KAR42365.1
KAR47781.1
KAR53520.1
KAR59580.1
KAR62590.1
KAR65670.1
KAR71957.1
KAR75790.1
KAR84018.1
KAR87544.1
KAR96280.1
KAS00180.1
KAS04488.1
KAS09807.1
KAS10682.1
KAS15395.1
KAS20657.1
KAS22679.1
KAS25119.1
KAS32689.1
KAS42329.1
KAS45264.1
KAS56322.1
KAS63079.1
KAS64101.1
KAS69926.1
KAS74055.1
KAS80178.1
KAS88832.1
KAS92059.1
KAS96648.1
KAT11448.1
KAT15945.1
KAT29239.1
KAT33821.1
KAT62402.1
KAU16005.1
KAU19854.1
KAU33744.1
KAU35263.1
KAU45711.1
KAU48491.1
KAU50694.1
KAU55288.1
KAU66336.1
KAU71763.1
KAU74092.1
KAU78729.1
KAU85442.1
KAU85634.1
KAU91809.1
KAU99701.1
KAV09293.1
KAV10220.1
KAV21589.1
KAV28669.1
KAV30756.1
KAV34090.1
KAV37723.1
KAV42014.1
KAV47834.1
KAV54234.1
KAV62192.1
KAV66427.1
KAV72309.1
KAV75346.1
KAV95835.1
KAV97704.1
KAW07879.1
KAW11680.1
KAW15634.1
KAW23671.1
KAW26237.1
KAW35156.1
KAW41227.1
KAW59903.1
KAW74620.1
KAW89561.1
KAW97672.1
KAX02441.1
KAX07814.1
KAX11022.1
KAX13965.1
KAX22925.1
KAX23331.1
KAX30146.1
KAX30693.1
KAX32635.1
KAX37945.1
KAX45327.1
KAX49468.1
KAX53959.1
KAX55776.1
KAX61613.1
KAX65173.1
KAX69283.1
KAX71515.1
KAX77931.1
KAX83382.1
KAX83996.1
KAX85817.1
KAX87788.1
KAX94924.1
KAY00590.1
KAY03052.1
KAY09296.1
KAY11393.1
KAY15893.1
KAY21995.1
KAY23152.1
KAY26274.1
KAY28489.1
KAY35413.1
KAY41799.1
KAY46431.1
KAY51575.1
KAY58477.1
KAY59933.1
KAY61253.1
KAY64066.1
KAY71148.1
KAY73471.1
KAY75298.1
KAY82460.1
KAY83097.1
KAY87301.1
KAY96557.1
KAY97373.1
KAZ01295.1
KAZ04529.1
KAZ15789.1
KAZ24172.1
KAZ28297.1
KAZ32321.1
KAZ33258.1
KAZ39829.1
KAZ43649.1
KAZ45226.1
KAZ51093.1
KAZ51660.1
KAZ53251.1
KAZ62579.1
KAZ62802.1
KAZ66753.1
KAZ74655.1
KAZ74830.1
KAZ91999.1
KAZ92197.1
KAZ96069.1
KAZ96768.1
KBA08011.1
KBA10400.1
KBA11824.1
KBA18410.1
KBA20761.1
KBA20971.1
KBA29039.1
KBA34446.1
KBA43513.1
KBA43684.1
KBA53037.1
KBA60276.1
KBA66253.1
KBA67784.1
KBA73575.1
KBA77117.1
KBA80296.1
KBA85469.1
KBA89621.1
KBA92293.1
KBB00446.1
KBB05487.1
KBB09281.1
KBB12467.1
KBB15806.1
KBB19126.1
KBB23941.1
KBB28630.1
KBB31760.1
KBB35536.1
KBB39833.1
KBB45175.1
KBB47055.1
KBB52799.1
KBB60267.1
KBB64563.1
KBB70040.1
KBB72038.1
KBB75098.1
KBB80801.1
KBB88904.1
KBB92656.1
KBB96537.1
KBC01092.1
KBC08810.1
KBC12585.1
KBC16814.1
KBC33133.1
KBC36429.1
KBC39605.1
KBC45415.1
KBC56000.1
KBC57340.1
KBC70436.1
KBC72248.1
KBC74185.1
KBC81239.1
KBC84159.1
KBC86234.1
KBC91669.1
KBC95079.1
KBC99715.1
KBD04077.1
KBD07783.1
KBD12710.1
KBD17043.1
KBD19874.1
KBD23480.1
KBD27552.1
KBD31592.1
KBD43615.1
KBD47164.1
KBD56116.1
KBD61360.1
KBD63434.1
KBD67266.1
KBD75089.1
KBD80387.1
KBD83762.1
KBD87775.1
KBD94084.1
KBE02536.1
KBE06838.1
KBE11587.1
KBE21283.1
KBE26760.1
KBE31262.1
KBE34609.1
KBE44088.1
KBE47097.1
KBE51063.1
KBE57180.1
KBE59340.1
KBE63670.1
KBE64940.1
KBE72909.1
KBE74636.1
KBE80540.1
KBE84984.1
KBE85876.1
KBE88378.1
KBE95311.1
KBE96818.1
KBF03838.1
KBF05113.1
KBF10803.1
KBF16258.1
KBF17852.1
KBF20395.1
KBF32243.1
KBF33467.1
KBF42417.1
KBF50200.1
KBF52156.1
KBF56626.1
KBF61438.1
KBF67266.1
KBF69899.1
KBF77415.1
KBF90084.1
KBF95019.1
KBG07643.1
KBG17159.1
KBG55951.1
KBG70422.1
KBH52274.1
KBI18208.1
KBI41479.1
KBI48724.1
KBI70081.1
KBJ00184.1
KBJ29850.1
KBJ33948.1
KBJ36596.1
KBJ41506.1
KBJ52859.1
KBJ59693.1
KBJ59894.1
KBJ64013.1
KBJ66725.1
KBJ67873.1
KBJ76902.1
KBJ82244.1
KBJ90028.1
KBJ93130.1
KBJ94613.1
KBJ97960.1
KBK06105.1
KBK10880.1
KBK29217.1
KBK29427.1
KBK38929.1
KBK41505.1
KBK44922.1
KBK47318.1
KBK50614.1
KBK59003.1
KBK69331.1
KBK75220.1
KBK76759.1
KBK83829.1
KBK92560.1
KBL02176.1
KBL09120.1
KBL14239.1
KBL15648.1
KBL16342.1
KBL21085.1
KBL26907.1
KBL30919.1
KBL42202.1
KBL44201.1
KBL47592.1
KBL51102.1
KBL61680.1
KBL72757.1
KBL75582.1
KBL83518.1
KBL86434.1
KBL90342.1
KBL92774.1
KBM02747.1
KBM10678.1
KBM11663.1
KBM20801.1
KBM29185.1
KBM30930.1
KBM37780.1
KBM40372.1
KBM45045.1
KBM46514.1
KBM48580.1
KBM64366.1
KBM66376.1
KBM76263.1
KBM81047.1
KBM85354.1
KBM86780.1
KBM91816.1
KBN05886.1
KBN11053.1
KBN19643.1
KBN25740.1
KBN27305.1
KBN29862.1
KBN35770.1
KBN36478.1
KBN43402.1
KBN43832.1
KBN45298.1
KBN50987.1
KBN56936.1
KBN59221.1
KBN61973.1
KBN69599.1
KBN72449.1
KBN79682.1
KBN86759.1
KBN86855.1
KBN91846.1
KBN97438.1
KBN97533.1
KBO04880.1
KBO07502.1
KBO08213.1
KBO16606.1
KBO17129.1
KBO20542.1
KBO32488.1
KBO36255.1
KBO37922.1
KBO40082.1
KBO47365.1
KBO52264.1
KBO58991.1
KBO61601.1
KBO62004.1
KBO69463.1
KBO71835.1
KBO76841.1
KBO77770.1
KBO83452.1
KBO87156.1
KBO89314.1
KBO97260.1
KBP00642.1
KBP05377.1
KBP09168.1
KBP10863.1
KBP16256.1
KBP22291.1
KBP23413.1
KBP29615.1
KBP30475.1
KBP35330.1
KBP36553.1
KBP41741.1
KBP46546.1
KBP62652.1
KBP64605.1
KBP67189.1
KBP72078.1
KBP84215.1
KBQ12435.1
KBQ17258.1
KBQ21886.1
KBQ27414.1
KBQ33568.1
KBQ43059.1
KBQ46611.1
KBQ57819.1
KBQ74801.1
KBQ78031.1
KBQ81064.1
KBQ83837.1
KBQ93801.1
KBQ95129.1
KBQ99600.1
KBR08227.1
KBR10251.1
KBR15007.1
KBR23990.1
KBR35239.1
KBR49108.1
KBR51487.1
KBR54176.1
KBR76861.1
KBR80540.1
KBR83783.1
KBR95919.1
KBR98962.1
KBS12195.1
KBS14076.1
KBS16391.1
KBS25461.1
KBS27482.1
KBS34360.1
KBS48504.1
KBS57578.1
KBS58407.1
KBS69853.1
KBS72718.1
KBS80585.1
KBS86554.1
KBS89881.1
KBS94334.1
KBS95145.1
KBT01329.1
KBT07876.1
KBT10537.1
KBT15607.1
KBT19729.1
KBT23930.1
KBT27061.1
KBT29996.1
KBT38571.1
KBT42062.1
KBT45496.1
KBT49069.1
KBT62030.1
KBT69977.1
KBT81430.1
KBT82115.1
KBT91918.1
KBT94271.1
KBU01684.1
KBU04367.1
KBU13108.1
KBU20726.1
KBU29518.1
KBU39444.1
KBU45136.1
KBU47233.1
KBU51765.1
KBU54353.1
KBU62134.1
KBU65661.1
KBU70951.1
KBU75116.1
KBU78879.1
KBU86124.1
KBU87820.1
KBU88644.1
KBU97550.1
KBU98901.1
KBV05816.1
KBV08335.1
KBV10984.1
KBV13596.1
KBV18884.1
KBV28864.1
KBV34456.1
KBV37655.1
KBV48785.1
KBV54027.1
KBV56617.1
KBV60457.1
KBV70156.1
KBV77134.1
KBW04599.1
KBW23512.1
KBW65301.1
KBW92111.1
KBX20379.1
KBX22255.1
KBX40305.1
KBX46182.1
KBX47854.1
KBX52713.1
KBX54168.1
KBX68816.1
KBX70679.1
KBX77157.1
KBX79660.1
KBX82234.1
KBX96920.1
KBX98094.1
KBY08919.1
KBY15503.1
KBY17906.1
KBY22354.1
KBY34859.1
KBY39850.1
KBY44048.1
KBY50235.1
KBY52389.1
KBY55845.1
KBY60143.1
KBY66282.1
KBY73063.1
KBY79104.1
KBY82114.1
KBZ06342.1
KBZ22028.1
KBZ23565.1
KBZ24161.1
KBZ30278.1
KBZ32908.1
KBZ37763.1
KBZ48185.1
KBZ50832.1
KBZ77303.1
KBZ80020.1
KBZ82554.1
KBZ94558.1
KBZ96502.1
KCA04108.1
KCA06337.1
KCA08278.1
KCA10310.1
KCA11963.1
KCA22320.1
KCA35485.1
KCA58884.1
KCA59085.1
KCA66005.1
KCA75274.1
KCA78845.1
KCA78981.1
KCA92877.1
KCB00926.1
KCB02125.1
KCB09971.1
KCB14963.1
KCB20492.1
KCB54344.1
KCB59523.1
KCB62803.1
KCB66235.1
KCB68459.1
KCB74805.1
KCB83127.1
KCB83194.1
KCB90136.1
KCC42208.1
KCC74213.1
KCC84144.1
KCC90139.1
KCD03869.1
KCD11978.1
KCD18317.1
KCD22596.1
KCD24547.1
KCD30674.1
KCD34358.1
KCD42901.1
KCD44455.1
KCD53635.1
KCD57112.1
KCD62396.1
KCD66926.1
KCD68109.1
KCD74251.1
KCD75872.1
KCD87167.1
KCD89384.1
KCD94311.1
KCD97173.1
KCE04127.1
KCE05882.1
KCE10366.1
KCE14051.1
KCE17483.1
KCE21133.1
KCE26341.1
KCE34569.1
KCE35335.1
KCE54961.1
KCE55119.1
KCE63952.1
KCE72077.1
KCE78026.1
KCE94059.1
KCE96848.1
KCF02030.1
KCF06823.1
KCF09493.1
KCF15124.1
KCF15496.1
KCF22963.1
KCF23955.1
KCF31930.1
KCF36001.1
KCF44418.1
KCF47182.1
KCF51109.1
KCF55895.1
KCF56280.1
KCF62205.1
KCF72389.1
KCF75311.1
KCF77301.1
KCF83493.1
KCF90529.1
KCF96386.1
KCF97153.1
KCG02598.1
KCG03758.1
KCG10853.1
KCG12854.1
KCG21558.1
KCG35710.1
KCG37189.1
KCG42584.1
KCG45281.1
KCG49328.1
KCG57110.1
KCG60354.1
KCG65003.1
KCG66278.1
KCG70286.1
KCG71589.1
KCG80876.1
KCG87392.1
KCG95622.1
KCH08390.1
KCH11468.1
KCH12100.1
KCH22112.1
KCH28727.1
KCH34692.1
KCH35218.1
KCH43470.1
KCH47529.1
KCH49747.1
KCH54964.1
KCH57633.1
KCH61066.1
KCH65814.1
KCH68148.1
KCH73660.1
KCH82745.1
KCH88912.1
KCH95990.1
KCH98000.1
KCI00022.1
KCI06766.1
KCI07677.1
KCI23286.1
KCI28405.1
KCI33621.1
KCI35527.1
KCI40803.1
KCI55900.1
KCI64318.1
KCI66517.1
KCI70950.1
KCI76150.1
KCI76362.1
KCI81414.1
KCI86458.1
KCI94160.1
KCJ02472.1
KCJ11201.1
KCJ28990.1
KCJ29458.1
KCJ33348.1
KCJ38790.1
KCJ42705.1
KCJ49186.1
KCJ51244.1
KCJ55202.1
KCJ57544.1
KCJ61723.1
KCJ68444.1
KCJ71595.1
KCJ74011.1
KCJ76368.1
KCK27010.1
KCK28762.1
KCK34819.1
KCK38932.1
KCK42220.1
KCK49735.1
KCK55683.1
KCK55914.1
KCK64661.1
KCK67704.1
KCK70051.1
KCK75970.1
KCK77197.1
KCK84568.1
KCK85092.1
KCK93024.1
KCK93634.1
KCL00555.1
KCL03721.1
KCL12130.1
KCL24417.1
KCL40410.1
KCL42072.1
KCL46653.1
KCL47513.1
KCL70099.1
KCL75471.1
KCL78673.1
KCL86280.1
KCL88467.1
KCL92748.1
KCM10633.1
KCM16086.1
KCM26302.1
KCM28856.1
KCM34033.1
KCM34759.1
KCM42511.1
KCM50953.1
KCM54855.1
KCM63866.1
KCM66077.1
KCM70132.1
KCM72020.1
KCM79102.1
KCM79305.1
KCM87720.1
KCM94685.1
KCM95783.1
KCN02479.1
KCN05387.1
KCN12088.1
KCN13686.1
KCN18588.1
KCN26615.1
KCN31193.1
KCN36060.1
KCN42241.1
KCN46349.1
KCN50770.1
KCN54471.1
KCN62094.1
KCN77281.1
KCN84777.1
KCN86157.1
KCN91835.1
KCN97008.1
KCO12442.1
KCO28860.1
KCO30098.1
KCO37783.1
KCO38030.1
KCO43652.1
KCO51372.1
KCO56541.1
KCO66321.1
KCO70994.1
KCO75874.1
KCO93680.1
KCO94928.1
KCO99824.1
KCP06611.1
KCP09345.1
KCP11399.1
KCP15334.1
KCP18545.1
KCP23066.1
KCP27093.1
KCP31807.1
KCP33892.1
KCP39712.1
KCP43878.1
KCP51457.1
KCP54084.1
KCP62517.1
KCP71735.1
KCP78611.1
KCP83754.1
KCP85357.1
KCP98965.1
KCP99510.1
KCQ09718.1
KCQ12552.1
KCQ15385.1
KCQ24149.1
KCQ25669.1
KCQ31138.1
KCQ38429.1
KCQ42969.1
KCQ51406.1
KCQ59267.1
KCQ62029.1
KCQ71369.1
KCQ80709.1
KCQ87924.1
KCQ99426.1
KCR03619.1
KCR05353.1
KCR13468.1
KCR17582.1
KCR27740.1
KCR28854.1
KCR39234.1
KCR42284.1
KCR47543.1
KCR61859.1
KCR62486.1
KCR65753.1
KCR71427.1
KCR78911.1
KCR82911.1
KCR85945.1
KCR94491.1
KCR95190.1
KCS00285.1
KCS06655.1
KCS13205.1
KCS13335.1
KCS19256.1
KCS25312.1
KCS29197.1
KCS30427.1
KCS33319.1
KCS40199.1
KCS45001.1
KCS45779.1
KCS49714.1
KCS57711.1
KCS60630.1
KCS73727.1
KCS74505.1
KCS81116.1
KCS87800.1
KCS88493.1
KCS95823.1
KCS96872.1
KCT07509.1
KCT11652.1
KCT17872.1
KCT24252.1
KCT24642.1
KCT34860.1
KCT37568.1
KCT44469.1
KCT45281.1
KCT50460.1
KCT55555.1
KCT66103.1
KCT68706.1
KCT72053.1
KCT74465.1
KCT79965.1
KCT82650.1
KCT87694.1
KCT89419.1
KCT95075.1
KCU03619.1
KCU07486.1
KCU08613.1
KCU17823.1
KCU24685.1
KCU25224.1
KCU35231.1
KCU44456.1
KCU53092.1
KCU60691.1
KCU65714.1
KCU71674.1
KCU77942.1
KCU82180.1
KCU85924.1
KDM95202.1
KEA68698.1
KEA70702.1
KEA79134.1
KEA81025.1
KEA86049.1
KEA92222.1
KEA95525.1
KEB01560.1
KEB03725.1
KEB09122.1
KEB13138.1
KEB15088.1
KEB20064.1
KEB20687.1
KEB26976.1
KEB33395.1
KEB33533.1
KEB39490.1
KEB51795.1
KEB53202.1
KEB58554.1
KEB59480.1
KEB65929.1
KEB69568.1
KEB72545.1
KEB81405.1
KEC17616.1
KEC29569.1
KEC32156.1
KEC38262.1
KEC38359.1
KEC43218.1
KEC44891.1
KEC51280.1
KED06461.1
KEP58745.1
KEY08894.1
KFC55694.1
KFE92576.1
KFL39145.1
KFW37560.1
KFW39860.1
KFZ73349.1
KIN22538.1
KIU59686.1
KIX88509.1
NP_217449.1
WP_003414837.1
YP_006516387.1
A0A042R4F6
A0A045IDF5
A0A046R1D3
A0A047RUL6
A0A056FRL7
A0A0B6SZC4
A1KMS8
A5U6U0
A5WRI5
C1AG49
D6FKG8
I6X5S4
P96202 [P]
P96202.2
Q7TXL8.1
1PQW
Polyketide synthase extender module 2 {ECO:0000313|EMBL:AAG23265.1} Saccharopolyspora spinosa. AAG23265.1

Q9ALM5 [P]
3SLK
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Homo sapiens (Human). AAA73576.1
AAB35516.1
AAC50259.1
AAH07267.1
AAH07909.1
AAH14634.2
AAH63242.1
AAS09886.1
BAE06070.1
BAG10519.1
NP_004095.4
XP_011521840.1
P49327 [P]
P49327.3
4W82
4W9N
Fatty acid synthase {ECO:0000313|EMBL:ABR09275.1} Sus scrofa (Pig). ABR09275.1
NP_001093400.1
A5YV76 [P]
2VZ8
2VZ9