ThYme: Thioester-active Enzymes

Family KR4

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Names of enzymes and/or genes present

Ketoacyl-ACP reductase

EC numbers

1.1.1.100 (3-oxoacyl-[acyl-carrier-protein] reductases)

Catalytic residues
Notes

1. KR domain of fatty acid synthases (FAS) and of polyketide synthases (PKS)
2. Shares some sequences with ER4 (different domains)

Numbers [P] (Evidence at Protein Level) = 50
[T] (Evidence at Transcript Level) = 41
PDBs = 15
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
ORF 1 2.3.1.94
Saccharopolyspora erythraea (Streptomyces erythraeus). AAA26493.2
AAA26504.1

Q03131 [P]
Q03131.1
2FR0
2FR1
Polyketide synthase extender modules 3-4 {ECO:0000313|EMBL:AAG23266.1} Saccharopolyspora spinosa. AAG23266.1

Q9ALM4 [P]
4IMP
Polyketide synthase extender module 2 {ECO:0000313|EMBL:AAG23265.1} Saccharopolyspora spinosa. AAG23265.1

Q9ALM5 [P]
3SLK
Tylactone synthase starter module and modules 1 & 2 {ECO:0000313|EMBL:AAB66504.1} Streptomyces fradiae (Streptomyces roseoflavus). AAB66504.1

O33954 [P]
2Z5L
AmphB {ECO:0000313|EMBL:AAK73513.1} Streptomyces nodosus. AAK73513.1

Q93NW7 [P]
3MJC
3MJE
3MJS
3MJT
3MJV
4DIF
AmphI {ECO:0000313|EMBL:AAK73501.1} Streptomyces nodosus. AAK73501.1

Q93NX9 [P]
4L4X
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Homo sapiens (Human). AAA73576.1
AAB35516.1
AAC50259.1
AAH07267.1
AAH07909.1
AAH14634.2
AAH63242.1
AAS09886.1
BAE06070.1
BAG10519.1
NP_004095.4
XP_011521840.1
P49327 [P]
P49327.3
4PIV
Fatty acid synthase {ECO:0000313|EMBL:ABR09275.1} Sus scrofa (Pig). ABR09275.1
NP_001093400.1
A5YV76 [P]
2VZ8
2VZ9