ThYme: Thioester-active Enzymes

Family TE16

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Fold α/β-Hydrolase
Names of enzymes and/or genes present 1. TE domain of fatty acid synthase (FAS) or thioesterase I
2. TE domain of polyketide synthase (PKS) or non-ribosomal
peptide synthase (NRP), or type I thioesterases (TE I)
EC numbers 1. 3.1.2.14 (oleoyl-ACP hydrolase) thioesterase domain
2. FAS, PKS and NRPS can have 2.3.1.85, 2.3.1.94, 2.3.1.-, 2.7.7.-, 5.1.1.-
Catalytic residues Ser, His, Asp
Notes

1. Long-chain acyl-ACP activity
2. Part of large multimodular PKS, NRPS, FAS
3. For non-ribosomal peptide synthases (NRPs) polypeptide carrier protein (PCP) is used instead of ACP as the carrier molecule.
 

Numbers [P] (Evidence at Protein Level) = 16
[T] (Evidence at Transcript Level) = 33
PDBs = 13
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Surfactin synthase subunit 3 Bacillus subtilis (strain 168). AFQ56286.1
AGG59694.1
AHA76317.1
AIC38727.1
AIC42959.1
AIY91633.1
AIY95942.1
AJE93032.1
BAA08985.1
BAM49281.1
BAM56551.1
CAA49818.1
CAB12145.2
CEI55470.1
EHA29021.1
EME05085.1
KFH30027.1
KFH34847.1
KIX81192.1
NP_388233.2
WP_003234570.1
A0A0A1M957
G4F045
L8ACT2
Q08787 [P]
Q08787.2
1JMK
2VSQ
Dimodular nonribosomal peptide synthase Bacillus subtilis (strain 168). AAC44634.1
AAD56240.1
AFQ59041.1
AGG62601.1
AHA79122.1
AIC41664.1
AIC45895.1
AIY94515.1
AIY98825.1
AJE95895.1
BAM55266.1
BAM59279.1
CAB15186.3
CEI58446.1
KFH30910.1
KFH32730.1
KIX81680.1
NP_391076.3
WP_009968094.1
A0A0A1M8B3
L8AUM1
P45745 [P]
P45745.4

Plipastatin synthase subunit E {ECO:0000313|EMBL:CEI57024.1} 2.3.1.-
Bacillus subtilis. AFQ57766.1
AGG61206.1
AHA77871.1
AIC40255.1
AIC44487.1
AIY93142.1
AIY97450.1
AJE94522.1
BAM52485.1
BAM58061.1
CAA74213.1
CAB13713.1
CEI57024.1
KIX83097.1
NP_389712.1
WP_009967353.1
WP_010886522.1
A0A0A1MD49
L8ALS6
O31827 [P]
O31827.1

Polyketide synthase PksR {ECO:0000313|EMBL:CEI56906.1} 2.3.1.-
Bacillus subtilis. AFQ57654.1
AGG61093.1
AHA77749.1
AIC40139.1
AIC44371.1
AIY93023.1
AIY97332.1
AJE94403.1
BAM57945.1
CAB13606.2
CEI56906.1
EME07445.1
KFH32910.1
KFH33806.1
KIX82979.1
NP_389604.2
WP_003245624.1
A0A0A1MEV4
O31784 [P]
O31784.2
4U3V
Leucine activase Brevibacillus brevis (Bacillus brevis). BAA00778.1
BAA06146.1

P0C064 [P]
P0C064.2

Leucine activase Brevibacillus parabrevis. AAC45930.1

O30409 [P]

Seryl-AMP ligase 2.7.7.-
Escherichia coli (strain K12). AAA23727.1
AAA23759.1
AAA92015.1
AAB40785.1
AAC73687.1
ACB01709.1
ACB01810.1
ACR63036.1
ACX40668.1
AEE55263.1
AEJ55215.1
AIF35957.1
AIN31077.1
AIZ31106.1
AIZ54431.1
AIZ92269.1
AJB50751.1
BAE76341.1
BAJ42412.1
BAL37750.1
CBJ00122.1
CCP98583.1
CDJ71047.1
CDK81369.1
CDP72454.1
CDU39645.1
CDY55903.1
CDZ19454.1
CEE06953.1
EFJ64005.1
EFK13261.1
EGB39159.1
EGB67336.1
EGU26003.1
EGV46934.1
EGW98185.1
EGX12741.1
EGX20519.1
EHV66436.1
EHV76259.1
EHV79300.1
EHV99851.1
EIE36043.1
EIF16719.1
EIG49634.1
EII47996.1
EII78743.1
EIJ05472.1
EKI23557.1
EKI30542.1
ELC63993.1
ELE04721.1
ELE12918.1
ELF01862.1
ELF22026.1
ELF26744.1
ELF77518.1
ELG96444.1
ELH50139.1
EMD14611.1
EMR97884.1
EMV47410.1
EMX26606.1
EMX32470.1
EMZ88108.1
EMZ95517.1
ENA07655.1
ENA24835.1
ENA34593.1
ENA56657.1
ENB24845.1
ENB40456.1
ENB90095.1
ENC07391.1
END60157.1
ENE12378.1
ENF87358.1
ENF93770.1
ENF99496.1
ENG21984.1
EOU70220.1
EOV15306.1
EOV54950.1
EOV83298.1
EOW62125.1
EQS85052.1
EQU64668.1
EQW98065.1
EQX59770.1
EQX69286.1
EQX87669.1
EQY83460.1
EQZ04327.1
EQZ04777.1
EQZ43173.1
EQZ45960.1
ERA22346.1
ERB04922.1
ERB23855.1
ERB32343.1
ESE04129.1
ESL25859.1
ESP49454.1
EST60505.1
EST77552.1
ETS24473.1
EYD90367.1
EYE05090.1
EYE06106.1
EYV89874.1
EZA32101.1
EZA70201.1
EZA70628.1
EZJ29366.1
EZJ74178.1
EZK09875.1
KDA86177.1
KDA91326.1
KDT03307.1
KDT22574.1
KDT36566.1
KDT53546.1
KDT68995.1
KDT72743.1
KDT77907.1
KDU08950.1
KDU37402.1
KDU44628.1
KDU60933.1
KDV88010.1
KDV91864.1
KDW11412.1
KDW49416.1
KDW93074.1
KDX55071.1
KDY20370.1
KDY39533.1
KDY50199.1
KDY57806.1
KDY58685.1
KDY79536.1
KDZ82776.1
KDZ84956.1
KEK91776.1
KEK92486.1
KEL06149.1
KEL24309.1
KEL33855.1
KEL37221.1
KEM11737.1
KEM40068.1
KEM47206.1
KEM66711.1
KEM78044.1
KEN06758.1
KEN29509.1
KEN47369.1
KEN60119.1
KEN62678.1
KEN79640.1
KFF40106.1
KFF51996.1
KGA87328.1
KGL67939.1
KGM64039.1
KGM68427.1
KGM77973.1
KGM80682.1
KGP09429.1
KGP12374.1
KGP39101.1
KGT07327.1
KGT20691.1
KGT23759.1
KHD39874.1
KHD47310.1
KHD57232.1
KHD59551.1
KHH67509.1
KHH92975.1
KHH93992.1
KHI18832.1
KHI54515.1
KIG38061.1
KIG70180.1
KIH01329.1
KIZ63373.1
KIZ67270.1
KIZ79932.1
KIZ85821.1
KIZ86693.1
KIZ87666.1
KIZ98100.1
KJA00243.1
KJA05175.1
KJD89972.1
NP_415118.1
WP_000077805.1
YP_001729487.1
YP_001729588.1
YP_488875.1
A0A024L6G1
A0A071ASC1
A0A079AYC7
A0A079DC18
A0A079EY94
A0A079FJY5
B1X5Y3
C4ZV32
C9R1D5
D8AUB4
D8BA55
E3PGJ5
E9YDY2
G0FDQ6
G2AR14
I2XG76
L2ZIC3
L3L0Q6
L8C4Y9
M9FYF4
N2JKX3
P11454 [P]
P11454.3
S0VS81
S0ZFI3
S1FII2
T8T2S8
T8YTZ3
T9N0T5
T9P1P1
U0DD27
V1B4Q4
W1BPI2
W3ULI8
2ROQ
3TEJ
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase 6.3.2.26
Acremonium chrysogenum (Cephalosporium acremonium).

P25464 [P]
P25464.1

Fatty acid synthase {ECO:0000313|EMBL:AGR49310.1} Agrotis ipsilon (Black cutworm moth). AGR49310.1

U5KGX9 [T]

Fatty acid synthase {ECO:0000313|EMBL:AID66645.1} Agrotis segetum (turnip moth). AID66645.1

A0A068FRC8 [T]

Polyketide synthase {ECO:0000313|EMBL:AEH76763.1} Alternaria alternata (Alternaria rot fungus) (Torula alternata). AEH76763.1

F8R4Y0 [T]

Polyketide synthase {ECO:0000313|EMBL:AGF50217.1} Ascochyta anemones. AGF50217.1

M1MEV4 [T]

Polyketide synthase A 2.3.1.221
Aspergillus parasiticus. AAC41674.1
AAC41675.1
AAS66004.1
KJK60793.1

Q12053 [P]
Q12053.1
3ILS
Fatty acid synthase {ECO:0000313|EMBL:AEY83835.1} 2.3.1.85 {ECO:0000313|EMBL:AEY83835.1}
Bombus lucorum (White-tailed bumblebee). AEY83835.1

H6WCY9 [T]

Fatty acid synthase {ECO:0000313|EMBL:AEW43642.1} 2.3.1.85 {ECO:0000313|EMBL:AEW43642.1}
Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris). AEW43642.1
NP_001267840.1
G9JWG5 [T]

P270 {ECO:0000313|EMBL:AAB53258.1} Bombyx mori (Silk moth). AAB53258.1
NP_001037478.1
O01678 [T]

Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Bos taurus (Bovine). AAR17600.1
AAR19788.1
NP_001012687.1
Q71SP7 [T]
Q71SP7.1

Fatty acid synthase {ECO:0000313|EMBL:AJA33512.1} Bubalus bubalis (Domestic water buffalo). AJA33512.1

A0A0A7RE76 [T]

Fatty acid synthase {ECO:0000313|EMBL:ACE00290.1} Caenorhabditis brenneri (Nematode worm). ACE00290.1

B3GNF0 [T]

Fatty acid synthase {ECO:0000313|EMBL:ABI95140.2} Capra hircus (Goat). ABI95140.2
NP_001272558.1
Q06B57 [T]

Fatty acid synthase {ECO:0000313|EMBL:ABB36643.1} Capra hircus (Goat). ABB36643.1

Q076H7 [T]

Fatty acid synthase {ECO:0000313|EMBL:JAB92698.1} Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
XP_004524715.1
XP_004524716.1
W8B6N0 [T]

Polyketide synthase {ECO:0000313|EMBL:AAT69682.1} Cercospora nicotianae (Barn spot disease fungus). AAT69682.1

Q6DQW3 [T]

Putative fatty acid synthase 1 {ECO:0000313|EMBL:AHL67652.1} Chilo suppressalis (striped riceborer). AHL67652.1

W8R9W4 [T]

Type I polyketide synthase {ECO:0000313|EMBL:AFB81352.1} Cladonia macilenta. AFB81352.1

H6WYN7 [T]

Beta-ketoacyl synthase domain-containing protein {ECO:0000313|EMBL:EFQ29059.1} Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola). ACN32207.2
EFQ29059.1

C9W7X1 [T]
E3QDX1

BcDNA.GH07626 {ECO:0000313|EMBL:AAD38618.1} Drosophila melanogaster (Fruit fly). AAD38618.1

Q7KML1 [T]

GH17750p {ECO:0000313|EMBL:ACJ13230.1} Drosophila melanogaster (Fruit fly). ACJ13230.1

B6IDT3 [T]

GH02912p {ECO:0000313|EMBL:AAM52599.1} Drosophila melanogaster (Fruit fly). AAM52599.1

Q8MR70 [T]

V(2)k05816, isoform A {ECO:0000313|EMBL:AAF51149.1} 1.-.-.- {ECO:0000313|EMBL:AAF51149.1}
2.3.1.38 {ECO:0000313|EMBL:AAF51149.1}
2.3.1.39 {ECO:0000313|EMBL:AAF51149.1}
2.3.1.41 {ECO:0000313|EMBL:AAF51149.1}
3.1.-.- {ECO:0000313|EMBL:AAF51149.1}
Drosophila melanogaster (Fruit fly). AAF51149.1
ACZ67868.1
NP_647613.1
Q9VQL6 [T]

TdiA {ECO:0000313|EMBL:ABU51602.1} Emericella nidulans (Aspergillus nidulans). ABU51602.1

A7XRY0 [T]

Conidial yellow pigment biosynthesis polyketide synthase 2.3.1.-
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans). CAA46695.2
CBF74114.1
EAA58778.1
XP_681478.1
Q03149 [P]
Q03149.2

Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase 6.3.2.26
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans). AAA03914.1
CAA38631.1
CBF84349.1
EAA62968.1
XP_660225.1
P27742 [P]
P27742.2

Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Gallus gallus (Chicken). AAA48767.1
AAA82106.1
AAB46389.1

P12276 [P]
P12276.5

Polyketide synthase 1 {ECO:0000313|EMBL:BAO20284.1} Grifola frondosa (Maitake) (Polyporus frondosus). BAO20284.1

V5YSL8 [T]

Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Homo sapiens (Human). AAA73576.1
AAB35516.1
AAC50259.1
AAH07267.1
AAH07909.1
AAH14634.2
AAH63242.1
AAS09886.1
BAE06070.1
BAG10519.1
NP_004095.4
XP_011521840.1
P49327 [P]
P49327.3
1XKT
2PX6
3TJM
Fatty acid synthase {ECO:0000313|EMBL:ADM88556.1} Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei). ADM88556.1

F8RHR0 [T]

Polyketide synthase {ECO:0000313|EMBL:CAC94008.1} Monascus purpureus (Monascus anka). CAC94008.1

Q8NJ18 [T]

Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Mus musculus (Mouse). AAG02285.1
AAH46513.1
AAH59850.1
BAC37895.1
CAA31525.1
CAM27545.1
NP_032014.3
P19096 [P]
P19096.2

Fatty acid synthase {ECO:0000313|EMBL:BAM19658.1} Papilio xuthus (Asian swallowtail butterfly). BAM19658.1

I4DP18 [T]

Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Rattus norvegicus (Rat). AAA41144.1
AAA41145.1
AAA57219.1
CAA31780.1
CAA31882.1
CAA44679.1
CAA44680.1
EDM06909.1
NP_059028.1
P12785 [P]
P12785.3

Polyketide synthase type I {ECO:0000313|EMBL:ABG91136.3} Rusavskia elegans. ABG91136.3

Q0Q2H9 [T]

Polyketide synthase {ECO:0000313|EMBL:AEE68982.1} Setosphaeria turcica (Northern leaf blight fungus) (Exserohilum turcicum). AEE68981.1
AEE68982.1

F6KVT1 [T]

Fatty acid synthase {ECO:0000313|EMBL:ABR09275.1} Sus scrofa (Pig). ABR09275.1
NP_001093400.1
A5YV76 [P]
2VZ8
2VZ9
Fatty acid synthase {ECO:0000313|EMBL:AAX55638.1} Sus scrofa (Pig). AAX55638.1

Q58G70 [T]

Fatty acid synthase {ECO:0000313|EMBL:AAX51683.1} Sus scrofa (Pig). AAX51683.1

Q58GK8 [T]

Non-reducing polyketide synthase {ECO:0000313|EMBL:AEM75019.1} Usnea longissima. AEM75019.1

G3LSH8 [T]

Type I polyketide synthase PKS6 {ECO:0000313|EMBL:AGI60158.1} Usnea longissima. AGI60158.1

S4UCE6 [T]

Polyketide synthase type I {ECO:0000313|EMBL:AII32482.1} Xanthoparmelia substrigosa. AII32482.1

A0A076GCA7 [T]