ThYme: Thioester-active Enzymes

Family TE16

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Fold α/β-Hydrolase
Names of enzymes and/or genes present 1. TE domain of fatty acid synthase (FAS) or thioesterase I
2. TE domain of polyketide synthase (PKS) or non-ribosomal
peptide synthase (NRP), or type I thioesterases (TE I)
EC numbers 1. 3.1.2.14 (oleoyl-ACP hydrolase) thioesterase domain
2. FAS, PKS and NRPS can have 2.3.1.85, 2.3.1.94, 2.3.1.-, 2.7.7.-, 5.1.1.-
Catalytic residues Ser, His, Asp
Notes

1. Long-chain acyl-ACP activity
2. Part of large multimodular PKS, NRPS, FAS
3. For non-ribosomal peptide synthases (NRPs) polypeptide carrier protein (PCP) is used instead of ACP as the carrier molecule.
 

Numbers [P] (Evidence at Protein Level) = 16
[T] (Evidence at Transcript Level) = 33
PDBs = 13
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
fengycin synthetase Bacillus subtilis AAB00093.1

Q45563
2CB9
2CBG
Surfactin synthase subunit 3 Bacillus subtilis (strain 168). AFQ56286.1
AGG59694.1
AHA76317.1
AIC38727.1
AIC42959.1
AIY91633.1
AIY95942.1
AJE93032.1
BAA08985.1
BAM49281.1
BAM56551.1
CAA49818.1
CAB12145.2
CEI55470.1
EHA29021.1
EME05085.1
KFH30027.1
KFH34847.1
KIX81192.1
NP_388233.2
WP_003234570.1
A0A0A1M957
G4F045
L8ACT2
Q08787 [P]
Q08787.2
1JMK
2VSQ
Polyketide synthase PksR {ECO:0000313|EMBL:CEI56906.1} 2.3.1.-
Bacillus subtilis. AFQ57654.1
AGG61093.1
AHA77749.1
AIC40139.1
AIC44371.1
AIY93023.1
AIY97332.1
AJE94403.1
BAM57945.1
CAB13606.2
CEI56906.1
EME07445.1
KFH32910.1
KFH33806.1
KIX82979.1
NP_389604.2
WP_003245624.1
A0A0A1MEV4
O31784 [P]
O31784.2
4U3V
Seryl-AMP ligase 2.7.7.-
Escherichia coli (strain K12). AAA23727.1
AAA23759.1
AAA92015.1
AAB40785.1
AAC73687.1
ACB01709.1
ACB01810.1
ACR63036.1
ACX40668.1
AEE55263.1
AEJ55215.1
AIF35957.1
AIN31077.1
AIZ31106.1
AIZ54431.1
AIZ92269.1
AJB50751.1
BAE76341.1
BAJ42412.1
BAL37750.1
CBJ00122.1
CCP98583.1
CDJ71047.1
CDK81369.1
CDP72454.1
CDU39645.1
CDY55903.1
CDZ19454.1
CEE06953.1
EFJ64005.1
EFK13261.1
EGB39159.1
EGB67336.1
EGU26003.1
EGV46934.1
EGW98185.1
EGX12741.1
EGX20519.1
EHV66436.1
EHV76259.1
EHV79300.1
EHV99851.1
EIE36043.1
EIF16719.1
EIG49634.1
EII47996.1
EII78743.1
EIJ05472.1
EKI23557.1
EKI30542.1
ELC63993.1
ELE04721.1
ELE12918.1
ELF01862.1
ELF22026.1
ELF26744.1
ELF77518.1
ELG96444.1
ELH50139.1
EMD14611.1
EMR97884.1
EMV47410.1
EMX26606.1
EMX32470.1
EMZ88108.1
EMZ95517.1
ENA07655.1
ENA24835.1
ENA34593.1
ENA56657.1
ENB24845.1
ENB40456.1
ENB90095.1
ENC07391.1
END60157.1
ENE12378.1
ENF87358.1
ENF93770.1
ENF99496.1
ENG21984.1
EOU70220.1
EOV15306.1
EOV54950.1
EOV83298.1
EOW62125.1
EQS85052.1
EQU64668.1
EQW98065.1
EQX59770.1
EQX69286.1
EQX87669.1
EQY83460.1
EQZ04327.1
EQZ04777.1
EQZ43173.1
EQZ45960.1
ERA22346.1
ERB04922.1
ERB23855.1
ERB32343.1
ESE04129.1
ESL25859.1
ESP49454.1
EST60505.1
EST77552.1
ETS24473.1
EYD90367.1
EYE05090.1
EYE06106.1
EYV89874.1
EZA32101.1
EZA70201.1
EZA70628.1
EZJ29366.1
EZJ74178.1
EZK09875.1
KDA86177.1
KDA91326.1
KDT03307.1
KDT22574.1
KDT36566.1
KDT53546.1
KDT68995.1
KDT72743.1
KDT77907.1
KDU08950.1
KDU37402.1
KDU44628.1
KDU60933.1
KDV88010.1
KDV91864.1
KDW11412.1
KDW49416.1
KDW93074.1
KDX55071.1
KDY20370.1
KDY39533.1
KDY50199.1
KDY57806.1
KDY58685.1
KDY79536.1
KDZ82776.1
KDZ84956.1
KEK91776.1
KEK92486.1
KEL06149.1
KEL24309.1
KEL33855.1
KEL37221.1
KEM11737.1
KEM40068.1
KEM47206.1
KEM66711.1
KEM78044.1
KEN06758.1
KEN29509.1
KEN47369.1
KEN60119.1
KEN62678.1
KEN79640.1
KFF40106.1
KFF51996.1
KGA87328.1
KGL67939.1
KGM64039.1
KGM68427.1
KGM77973.1
KGM80682.1
KGP09429.1
KGP12374.1
KGP39101.1
KGT07327.1
KGT20691.1
KGT23759.1
KHD39874.1
KHD47310.1
KHD57232.1
KHD59551.1
KHH67509.1
KHH92975.1
KHH93992.1
KHI18832.1
KHI54515.1
KIG38061.1
KIG70180.1
KIH01329.1
KIZ63373.1
KIZ67270.1
KIZ79932.1
KIZ85821.1
KIZ86693.1
KIZ87666.1
KIZ98100.1
KJA00243.1
KJA05175.1
KJD89972.1
NP_415118.1
WP_000077805.1
YP_001729487.1
YP_001729588.1
YP_488875.1
A0A024L6G1
A0A071ASC1
A0A079AYC7
A0A079DC18
A0A079EY94
A0A079FJY5
B1X5Y3
C4ZV32
C9R1D5
D8AUB4
D8BA55
E3PGJ5
E9YDY2
G0FDQ6
G2AR14
I2XG76
L2ZIC3
L3L0Q6
L8C4Y9
M9FYF4
N2JKX3
P11454 [P]
P11454.3
S0VS81
S0ZFI3
S1FII2
T8T2S8
T8YTZ3
T9N0T5
T9P1P1
U0DD27
V1B4Q4
W1BPI2
W3ULI8
2ROQ
3TEJ
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Polyketide synthase A 2.3.1.221
Aspergillus parasiticus. AAC41674.1
AAC41675.1
AAS66004.1
KJK60793.1

Q12053 [P]
Q12053.1
3ILS
Oleoyl-[acyl-carrier-protein] hydrolase 1.1.1.100
1.3.1.39
2.3.1.38
2.3.1.39
2.3.1.41
2.3.1.85
3.1.2.14
4.2.1.59
Homo sapiens (Human). AAA73576.1
AAB35516.1
AAC50259.1
AAH07267.1
AAH07909.1
AAH14634.2
AAH63242.1
AAS09886.1
BAE06070.1
BAG10519.1
NP_004095.4
XP_011521840.1
P49327 [P]
P49327.3
1XKT
2PX6
3TJM
Fatty acid synthase {ECO:0000313|EMBL:ABR09275.1} Sus scrofa (Pig). ABR09275.1
NP_001093400.1
A5YV76 [P]
2VZ8
2VZ9