ThYme: Thioester-active Enzymes

Family ACS5

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Fold Flavodoxin-like (C-terminal domain)
Names of enzymes and/or genes present

Succinyl-CoA synthetase alpha chain (sucD)
Succinyl-CoA ligase subunit beta (sucC)
 

EC numbers

6.2.1.- (Unclassified acid-thiol ligase)
6.2.1.4 (Succinate-CoA ligase, GDP forming)
6.2.1.5 (Succinate-CoA ligase, ADP forming)
6.2.1.9 (Malate-CoA ligase)
 

Catalytic residues
Notes
Numbers [P] (Evidence at Protein Level) = 42
[T] (Evidence at Transcript Level) = 128
PDBs = 21
Archaea
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Succinyl-CoA ligase [ADP-forming] subunit alpha {ECO:0000256|RuleBase:RU000699} 6.2.1.5 {ECO:0000256|RuleBase:RU000699}
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1). BAA80057.2
NP_147697.2
WP_010866156.1
Q9YD40 [P]
2YV2
Succinyl-CoA synthetase subunit alpha 6.2.1.5
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii). AAB99250.1
NP_248241.1
WP_010870758.1
Q58643 [P]
Q58643.1
2YV1
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Succinyl-CoA synthetase subunit beta {ECO:0000256|HAMAP-Rule:MF_00558} 6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558}
6.2.1.5 {ECO:0000256|HAMAP-Rule:MF_00558}
Escherichia coli D6-113.11. AAA23899.1
AAA23900.1
AAC73822.1
AAC73823.1
AAG55052.1
AAG55053.1
AAN79278.1
AAN79279.1
ABV05142.1
ABV18382.1
ACA78555.1
ACB01936.1
ACB19410.1
ACI36264.1
ACR65590.1
BAA35394.1
BAA35395.1
BAB34176.1
BAB34177.1
BAG76311.1
CAA33792.1
CAR12017.1
CAR16822.1
CAU96581.1
CCK45885.1
CCK45886.1
CDK46456.1
CDK80328.1
CDK80329.1
CDL06743.1
CDL06744.1
CDL24529.1
CDL24530.1
CDL49192.1
CDL49194.1
CDN81096.1
CDN81097.1
CDP67159.1
CDP67160.1
CDU34350.1
CDU34351.1
CEK03775.1
CEK03776.1
EDU91495.1
EDU91605.1
EDX29175.1
EDX29196.1
EFI87636.1
EFI87637.1
EFJ71651.1
EFJ71652.1
EFJ84744.1
EFJ84745.1
EFJ97761.1
EFK01140.1
EFK20673.1
EFK26069.1
EFK26070.1
EFK45594.1
EFK45595.1
EFK52127.1
EFK52128.1
EFK67286.1
EFK67287.1
EFK73322.1
EFK73323.1
EFK88663.1
EFK88664.1
EFO56226.1
EFO56227.1
EFU37613.1
EFU37614.1
EFX17352.1
EFX17353.1
EFZ56497.1
EFZ56498.1
EGB62854.1
EGB62855.1
EGB67232.1
EGB67233.1
EGB89584.1
EGB89585.1
EGE66028.1
EGE66029.1
EGI10246.1
EGI10247.1
EGI22061.1
EGI22062.1
EGI47199.1
EGI47200.1
EGI51758.1
EGI51759.1
EGP25991.1
EGP25992.1
EGU97731.1
EGW96367.1
EGW96368.1
EGW97222.1
EGW97223.1
EHP67666.1
EHV50691.1
EHV61950.1
EHV61951.1
EHW14343.1
EHW24020.1
EHW24021.1
EHW76932.1
EHW76933.1
EHX34537.1
EHX34538.1
EHX34887.1
EHX34888.1
EHX36488.1
EID66263.1
EID66264.1
EIG79156.1
EIG79231.1
EIG90091.1
EIG90192.1
EIH13547.1
EIH13602.1
EIH25812.1
EIH26547.1
EII10561.1
EII10681.1
EII22054.1
EII22083.1
EII33342.1
EII33755.1
EII44863.1
EII44955.1
EII57359.1
EII57456.1
EIL51485.1
EJE66325.1
EJE87363.1
EJE87364.1
EKJ26434.1
EKJ26435.1
EKJ81085.1
EKJ81086.1
ELC11110.1
ELC11111.1
ELC42803.1
ELC42804.1
ELC63356.1
ELC63357.1
ELE04059.1
ELE04060.1
ELE57600.1
ELE57601.1
ELE62661.1
ELF11083.1
ELF11084.1
ELI32409.1
ELI32410.1
ELI44219.1
ELI44220.1
ELJ75710.1
ELJ75711.1
ELW38482.1
ELW38483.1
EMU64687.1
EMU64688.1
EMU71427.1
EMU71428.1
EMV63901.1
EMV63969.1
EMV64140.1
EMV64515.1
EMV65331.1
EMW23582.1
EMW23583.1
EMW86466.1
EMW86467.1
EMX21997.1
EMX21998.1
EMX31574.1
EMX31575.1
EMX41261.1
EMX41262.1
EMX54464.1
EMX54465.1
EMX88637.1
EMX88638.1
ENA08909.1
ENA08910.1
ENA34736.1
ENA34737.1
ENA41219.1
ENA41220.1
ENB15492.1
ENB15493.1
ENB30263.1
ENB30264.1
ENB44776.1
ENB44777.1
ENC36879.1
ENC42120.1
ENC42121.1
ENC93183.1
ENC93184.1
END51797.1
END95193.1
END95194.1
ENG99498.1
ENG99499.1
ENH04332.1
ENH10596.1
ENH10597.1
EOQ57299.1
EOQ57300.1
EOU68855.1
EOU68856.1
EOU95229.1
EOU97909.1
EOV13181.1
EOV14951.1
EOV14952.1
EOV28603.1
EOV28604.1
EOV64692.1
EOV67576.1
EOV80354.1
EOV81801.1
EOV81802.1
EOV82972.1
EOV82973.1
EOV97506.1
EOW09137.1
EOW09138.1
EOW10121.1
EOW17142.1
EOW17143.1
EOW22602.1
EOW22603.1
EOW26882.1
EOW26883.1
EOW49840.1
EOW49841.1
EOX01826.1
EOX01827.1
EQN32157.1
EQN32158.1
EQO01377.1
EQO01378.1
EQP59544.1
EQP59545.1
EQQ15568.1
EQR44005.1
EQR44006.1
EQV94871.1
EQV94872.1
EQW96947.1
EQW96948.1
EQX58615.1
EQX58616.1
EQX68804.1
EQX89889.1
EQX89890.1
EQY67226.1
EQY67227.1
EQY76526.1
EQZ42290.1
EQZ42291.1
ERA10007.1
ERA10008.1
ERB08910.1
ERB08911.1
ERB31398.1
ERB31399.1
ESA28935.1
ESA60424.1
ESA60425.1
ESA62414.1
ESA62415.1
ESA64592.1
ESA75283.1
ESA75284.1
ESA82579.1
ESA82580.1
ESA94379.1
ESA94380.1
ESC91414.1
ESC91415.1
ESC97260.1
ESC97261.1
ESD05098.1
ESD05099.1
ESD28401.1
ESD32947.1
ESD32948.1
ESD37671.1
ESD37672.1
ESD66336.1
ESD66337.1
ESD68691.1
ESD68692.1
ESD70186.1
ESD70187.1
ESD86796.1
ESD86797.1
ESE00457.1
ESE00458.1
ESK11633.1
ESK11634.1
ESK40860.1
ESK40861.1
ESP10411.1
ESP10412.1
ETD60390.1
ETE28736.1
ETJ23373.1
ETJ23374.1
ETS24829.1
ETS24830.1
ETY50102.1
ETY50103.1
EYD86822.1
EYE29213.1
EYV14465.1
EYV14466.1
EYV61668.1
EYV61669.1
EYY76284.1
EYY76285.1
EZA36244.1
EZA36245.1
EZB64170.1
EZD30157.1
EZD90704.1
EZD90705.1
EZD96704.1
EZD96705.1
EZE10017.1
EZE10018.1
EZE31930.1
EZE31931.1
EZE48831.1
EZE48832.1
EZJ45048.1
EZJ45049.1
EZJ53985.1
EZJ53986.1
EZJ89269.1
EZJ89528.1
EZK24980.1
KDH00828.1
KDU17782.1
KDU17811.1
KDU25302.1
KDU25303.1
KDU32013.1
KDU32014.1
KDU55140.1
KDU55141.1
KDU62166.1
KDU62167.1
KDV35711.1
KDV35712.1
KDV38916.1
KDV38917.1
KDV59839.1
KDV59840.1
KDW33769.1
KDW33785.1
KDW71673.1
KDW84668.1
KDX18919.1
KDX18920.1
KDX84504.1
KDX84505.1
KDY15303.1
KDY15304.1
KDY16015.1
KDY16016.1
KDY51461.1
KDY51462.1
KDY57019.1
KDY57020.1
KDY61270.1
KDY61271.1
KDY86348.1
KDY86349.1
KDY93314.1
KDY93315.1
KDZ14953.1
KDZ14954.1
KDZ35937.1
KDZ64815.1
KDZ64816.1
KEJ50874.1
KEJ50877.1
KEJ52968.1
KEJ52969.1
KEJ61311.1
KEJ61312.1
KEJ64782.1
KEJ64783.1
KEJ70214.1
KEJ70215.1
KEJ72411.1
KEJ72412.1
KEL22019.1
KEL22020.1
KEL67279.1
KEL67280.1
KEM54568.1
KEN51360.1
KEN51361.1
KEN73033.1
KEN73039.1
KEN91992.1
KEN91993.1
KEN97444.1
KEN97445.1
KEO03410.1
KEO03411.1
KEO14441.1
KEO14442.1
KEO27760.1
KEO27761.1
KEO37400.1
KGM59773.1
KGM59774.1
NP_286444.1
NP_286445.1
NP_308780.1
NP_308781.1
NP_415256.1
NP_415257.1
NP_752735.1
NP_752736.1
YP_001457525.1
YP_001461887.1
YP_001725882.1
YP_001729714.1
YP_001742828.1
YP_002269351.1
YP_002292062.1
YP_002401818.1
YP_002406711.1
YP_002411563.1
YP_002925788.1
YP_489007.1
YP_489008.1
A0A017IJ70
A0A017M0K0
A0A024KQE8
A0A024KRG7
A0A025CI32
A0A025CLI0
A0A025GA81
A0A025GBP6
A0A026GZS2
A0A026H3B7
A0A026V2G4
A0A026V4Q8
A0A027FEG5
A0A027TYT1
A0A027YVK3
A0A027YWK9
A0A027ZCW7
A0A027ZDJ3
A0A028AFE6
A0A028AGM9
A0A028C8D8
A0A028C902
A0A028DLM1
A0A028DLP9
A0A029I8A5
A0A029I8X8
A0A029IZK4
A0A029IZU2
A0A029LV87
A0A029LVU0
A0A029PSL6
A0A064TWH7
A0A069X5M8
A0A069XCZ4
A0A069XP70
A0A069XWI6
A0A069Z666
A0A069ZCK7
A0A070D3Y0
A0A070D5K7
A0A070DD62
A0A070DEE0
A0A070F245
A0A070FBE5
A0A070KPQ6
A0A070KSN2
A0A070P357
A0A070Q583
A0A070SNJ0
A0A070SQ32
A0A070Y0L0
A0A070Y221
A0A071ADA4
A0A071AGH1
A0A071BUA5
A0A071BUW5
A0A071CAA3
A0A071CC57
A0A071D4D3
A0A071F1T9
A0A071F2R1
A0A073G0S4
A0A073GBZ2
A0A073GJH8
A0A073GV74
A0A073GYH4
A0A073GYV8
A0A073H5I7
A0A073HG49
A0A073T7S3
A0A073T8X0
A0A073UG78
A0A073UZ87
A0A074HRC1
A0A074HSJ0
A0A074I7H1
A0A074I949
A0A074IM44
A0A074INX9
A0A078ZZS3
A0A079A1A0
A0A079AY69
A0A079B185
A0A079CZ83
A0A079CZE5
A0A079CZS9
A0A079D2B6
A0A079F1D3
A0A079F3R4
A0A079FM56
A0A079FNJ0
A0A079GMB7
A0A079GSS0
A0A079XZ04
A0A079Y2D8
A0A079YCX9
A0A079YN35
A0A080C7R9
A0A080EQM8
A0A080EX47
A0A080G273
A0A080GAW3
A0A080GQG9
A0A080GXC2
A0A080IEV2
A0A080IJI7
A0A080JC41
A0A0A0FAA2
A0A0A0FBN1
A0A0A8U4U0
A0A0A8U9M0
A7ZJA8
A7ZXY8
B1IY02
B1LLG1
B1X6Q8
B3BGI7
B3BGI8
B3WQB2
B3WQB3
B5YQR7
B6I7Z9
B7LAD4
B7N9W6
B7NMS9
C4ZWK2
D7XDI8
D7XDI9
D7XV21
D7XV22
D7Y3N1
D7YNI6
D7ZSP8
D7ZSP9
D8A864
D8C0D1
D8C0D2
D8E8L4
D8E8L5
D8EK17
D8EK18
E1HTT5
E1HTT6
E1I2X5
E1I2X6
E1IWT2
E1IWT3
E1JA56
E1JA57
E6BD71
E6BD72
E7IGT5
E7IGT6
E8I580
E8I581
E9TB01
E9TB02
E9YEB7
E9YEB8
E9YRT2
E9YRT3
F1ZGG6
F1ZGG7
F4SKT9
F4SKU0
F4TBT1
F4TBT2
F4VBF8
F4VBF9
F4VSN2
F4VSN3
F7MUE1
F7MUE2
F8XBT9
G2ACJ8
G2ACJ9
G2ARH4
G2ARH5
H1BSD7
H4TYF8
H4UGV9
H4UGW0
H4YT90
H4ZRS3
H4ZRS4
H5DXF1
H5DXF2
H5IFX8
H5IFX9
H5IXD6
H5IXD7
H5JEU7
I0VQ47
I0VQ48
I2RA71
I2RAE6
I2RQ25
I2RQC6
I2SYE1
I2T0H6
I2VVX8
I2VW98
I2WBM6
I2WBQ5
I2WRG7
I2WSN0
I2X793
I2X7I5
I2XT97
I2XTJ4
I4SLZ4
J7QYV8
J7RP94
K3RRE7
K3SJJ9
K4UV78
K4X133
K4X4K3
K5BYD1
K5BZE7
L2V6G6
L2V9L0
L2XSQ8
L2XTV7
L2ZGN1
L2ZID8
L3KZ19
L3L0N5
L3QB89
L3QCU4
L3QQM6
L3UNL2
L3UR76
L4VXH9
L4VYK2
L4WWS6
L4WX74
L5HMG7
L5HNE5
L9IJV9
L9IP61
M8K3Q0
M8KMU9
M8L7V2
M8LSH0
M8U5J0
M8U6K8
M8YA08
M8YF92
M9DAE8
M9E336
M9FHX6
M9FVV1
M9GAI5
M9GG74
M9HR81
M9HW66
M9I1U7
M9IBL2
M9L6Y2
M9L9Z8
N2H3H4
N2H7M3
N2J531
N2JFL8
N2JQN5
N2JUW1
N2QVG9
N2R187
N2S2Q7
N2S489
N2TDK5
N2TEJ8
N3ARP5
N3BB47
N3BHS3
N3F7S6
N3F8H8
N3KH31
N3NI30
N3NSE5
N4NER8
N4NRW1
N4P1J0
N4PJH7
N4PQV6
P0A836 [P]
P0A837
P0A838
P0AGE9 [P]
P0AGF0
P0AGF1
R8XJD6
R8XK16
S0VN92
S0VY70
S0YAZ6
S0YJ13
S0Z9K9
S0ZEJ2
S0ZQ48
S1AHI8
S1B028
S1DNL2
S1DRH9
S1EPC8
S1ETL6
S1F4Z0
S1F8C7
S1FHJ8
S1G317
S1H1A9
S1HDC4
S1HP68
S1HRU5
S1I1A0
S1I437
S1IGD5
S1IGG1
S1ITT7
S1KBX2
S1L1W0
S1PKP0
S1QBH0
T5P9D3
T5PKB7
T5UV82
T5V5F3
T6HZD3
T6IET3
T6MKX8
T6XTN5
T6XYX0
T8JDW5
T8JLL1
T8SW35
T8TQD7
T8Y044
T8YQK7
T8ZML7
T9BAB1
T9BCY0
T9GU20
T9HLX8
T9IDD5
T9MWL2
T9NR65
T9T2D5
T9TEP9
U0BH65
U0CEK0
U0DAF1
U0ECL3
U9V8N8
U9XEH8
U9XK65
U9XTK4
U9XWF7
U9XZA4
U9YLC3
U9YLM9
U9Z714
U9ZLR5
V0A5T5
V0AKJ3
V0R9I8
V0RBV9
V0RMD4
V0RR34
V0SEI4
V0T073
V0U8V8
V0UIJ6
V0UX07
V0V0A9
V0VAL1
V0X8B3
V0XCH4
V0XF15
V0XJ02
V0XJC2
V0XN91
V0YWX9
V0Z0F6
V1A0Z4
V1A4E6
V2R1W2
V2SNY0
V2TSL4
V2TYQ0
V4BS28
V4BWZ6
V6E7K7
V6FIG8
V6FIM2
V8F8E3
V8KTL9
W1BI14
W1BLI7
W1DBJ7
W1DF76
W1EQS8
W1ESL8
W1GR80
W1GRF6
W1WZ62
W1X3T1
W3UPJ8
W3UPY0
W8ZNV2
W8ZPE7
X7PQW0
X7PTG6
1CQI
1CQJ
1JKJ
1JLL
1SCU
2NU6
2NU7
2NU8
2NU9
2NUA
2SCU
Succinyl-CoA synthetase subunit alpha 6.2.1.5
Thermus thermophilus. AAA27504.2
AEG32962.1
CAA38006.1
CAA38007.1
CAA39506.1
CAA39507.1
WP_014509987.1
WP_024118989.1
F6DEK7
P09143 [P]
P09143.1
P25126 [P]
P25126.1
1OI7
3UFX
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Succinyl-CoA synthetase beta-G chain 6.2.1.4
6.2.1.5
Sus scrofa (Pig). AAA31120.1
AAB94001.1
AAB94002.2
AAB94003.1
AAB94004.1
CAB03559.1
NP_999574.1
O19069 [P]
O19069.2
P53590 [P]
P53590.2
1EUC
1EUD
2FP4
2FPG
2FPI
2FPP