ThYme: Thioester-active Enzymes

Family ACS1

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Fold Acetyl-CoA synthetase-like
Names of enzymes and/or genes present

AMP-binding protein
Long-chain-fatty-acid-CoA ligase
FadD
4-chlorobenzoate-CoA ligase
Acetyl-CoA synthetase
acsA
Benzoate-CoA ligase
Short-chain-fatty-acid-CoA ligase
fadK
Long-chain-fatty-acid-ACP ligase
mbtM
4-hydroxybenzoyl-CoA synthetase
2-succinylbenzoate-CoA ligase
3-hydroxybenzoyl-CoA ligase
Medium-chain fatty acid-CoA ligase
4-coumarate-CoA ligase
4CLL1, 4CLL2, 4CLL5, 4CLL6, 4CLL7, 4CLL8, 4CLL9, 4CL1, 4CL2, 4CL3, 4CL4
Acetoacyl-CoA synthetase
Long-chain-acyl-CoA synthetase
LACS1, LACS2, LACS3, LASC4, LACS5, LACS6, LACS7, LACS8, LACS9,
Acyl-CoA synthetase mitochondrial
ACSM1, ACSM2, ACSM3, ACSM4, ACSM5
Fatty acyl-CoA synthetase A, fcsA
Acetyl-CoA synthetase, ACSS1, ACSS2
Acyl-CoA synthase family member, ACSF2, ACSF3

EC numbers

6.2.1.- (Unclassified acid-thiol ligase)
6.2.1.1 (Acetate-CoA ligase)
6.2.1.2 (Butyrate-CoA ligase)
6.2.1.3 (Long-chain fatty acid-CoA ligase)
6.2.1.12 (4-coumarate-CoA ligase)
6.2.1.16 (Acetoacetate-CoA ligase)
6.2.1.17 (Propionate-CoA ligase)
6.2.1.20 (Long-chain fatty acid-ACP ligase)
6.2.1.25 (Benzoate-CoA ligase)
6.2.1.26 (o-succinylbenzoate-CoA ligase)
6.2.1.27 (4-hydroxybenzoate-CoA ligase)
6.2.1.32 (Anthranilate-CoA ligase)
6.2.1.34 (trans-feruloyl-CoA synthase)

Catalytic residues
Notes

1. Other AMP binding domain containing proteins are present in this family that do not join acyl chains with CoA.

2. Some EC numbers included:
2.3.1.- (Acyltransferases, transferring groups other than amino-acyl)
2.7.7.- (Nucleotidyltransferases)
5.1.1.- (Racemases acting on Amino Acids and derivatives)
6.3.2.- (Peptide synthases)

Numbers [P] (Evidence at Protein Level) = 57
[T] (Evidence at Transcript Level) = 487
PDBs = 25
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
C Chain C, Crystal Structure Of Atp Bound Rpmatb-Bxbclm Chimera B1 Burkholderia xenovorans CAE25665.1
WP_011155789.1
Q13WK3
Q6ND88
4FUQ
4FUT
4GXQ
4GXR
A Chain A, Malonyl-Coa Ligase Ternary Product Complex With Malonyl-Coa And Amp Bound Streptomyces coelicolor CAB86109.1
NP_626687.1
WP_011028356.1
Q9L0A2
3NYQ
3NYR
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
4-coumaroyl-CoA synthase 1 6.2.1.12
Arabidopsis thaliana (Mouse-ear cress). AAA82888.1
AAD47191.1
AAG50881.1
AAL91633.1
AAM20598.1
AAM91412.1
AAQ86588.1
AEE32698.1
AEE32699.1
NP_175579.1
NP_849793.1
Q42524 [P]
Q42524-1
Q42524-2
Q42524.1
3TSY
Luciferase {ECO:0000313|EMBL:AAU85360.1} 1.13.12.7 {ECO:0000313|EMBL:AAU85360.1}
Lampyris turkestanicus (Iranian firefly). AAU85360.1

Q5UFR2 [P]
3QYA
4M46
Luciferin 4-monooxygenase 1.13.12.7
Luciola cruciata (Japanese firefly) (Genji firefly). AAA29135.1

P13129 [P]
P13129.1
2D1Q
2D1R
2D1S
2D1T
Luciferin 4-monooxygenase 1.13.12.7
Photinus pyralis (Common eastern firefly) (Lampyris pyralis). AAA03561.1
AAA29795.1
AAB64396.1
AAB64399.1
ACF93193.1
AFS30676.1
AGC54787.1
AHI96225.1
AHI96226.1
AHI96227.1
AHI96228.1
AHI96229.1
AHI96230.1
AHI96231.1
AHI96232.1
BAL46512.1
CAA59281.1
CAA59283.1

H1AD96 [T]
P08659 [P]
P08659.1
1BA3
1LCI
3IEP
3IER
3IES
3RIX
4E5D
4G36
4G37
4-coumarate:CoA ligase {ECO:0000313|EMBL:AAL02145.1} Populus tomentosa (Chinese white poplar). AAL02145.1

Q941M3 [P]
3A9U
3A9V
3NI2