ThYme: Thioester-active Enzymes

Family TE18

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Fold α/β-Hydrolase
Names of enzymes and/or genes present 1. S-acyl fatty acid synthetases/thioester hydrolases (Thioesterase II)
2. type II thioesterase (TE II)
EC numbers 3.1.2.- (thioester hydrolase)
3.1.2.14 (oleoyl-ACP hydrolase)
Catalytic residues Ser, His, Asp
Notes

1. Thioesterase II work with FASs to produce medium-chain (C8 to C12) fatty acids.
2. TE II enzymes remove aberrant acyl chains from PKS and NPRS.
3. These are independent enzymes, not a domain in FAS, PKS or NRPS.
 

Numbers [P] (Evidence at Protein Level) = 8
[T] (Evidence at Transcript Level) = 5
PDBs = 6
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
RifR {ECO:0000313|EMBL:AAG52991.1} Amycolatopsis mediterranei (Nocardia mediterranei). AAG52991.1

Q7BUF9 [P]
3FLA
3FLB
Surfactin synthetase {ECO:0000313|EMBL:EHA29020.1} 3.1.2.-
3.1.2.- {ECO:0000313|EMBL:AIX06068.1}
Bacillus subtilis subsp. subtilis str. SC-8. AFQ56287.1
AGG59695.1
AHA76318.1
AIC38728.1
AIC42960.1
AIC96980.1
AIX06068.1
AIY91634.1
AIY95943.1
AJE93033.1
BAA08986.1
BAI83824.1
CAA49819.1
CAB12146.1
CEI55471.1
EHA29020.1
EME05000.1
EXF52076.1
GAK82374.1
KDE24014.1
KFH30028.1
KFH34848.1
KIO56930.1
KIX81191.1
NP_388234.1
WP_003234568.1
A0A063XDF3
D4G518
G4F044
Q08788 [P]
Q08788.3
2RON
Surfactin synthetase {ECO:0000313|EMBL:EHA29020.1} 3.1.2.-
3.1.2.- {ECO:0000313|EMBL:AIX06068.1}
Brevibacillus parabrevis.

O30409 [P]
2K2Q
D Chain D, Redj-Thioesterase From The Prodiginine Biosynthetic Pathway In Streptomyces Coelicolor Streptomyces coelicolor CAA16185.1
NP_630015.1
O54157
3QMV
3QMW