ThYme: Thioester-active Enzymes

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Fold α/-Hydrolase
Names of enzymes and/or genes present Palmitoyl-protein thioesterase (ppt1, ppt2)
EC numbers 3.1.2.- (thioester hydrolase)
3.1.2.22 (palmitoyl-protein hydrolase)
Catalytic residues Ser, His, Asp
Notes

1. Palmitoyl-protein activity.
2. Mutations in PPT gene have been linked to neuronal ceroid lipofuscinosis, a genetic neurogenerative disorder.


 

Numbers [P] (Evidence at Protein Level) = 6
[T] (Evidence at Transcript Level) = 67
PDBs = 5
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Fatty alcohol acetyltransferase {ECO:0000313|EMBL:AIN34691.1} Agrotis segetum (turnip moth). AIN34691.1

A0A088M9W1 [T]

Fatty alcohol acetyltransferase {ECO:0000313|EMBL:AIN34684.1} Agrotis segetum (turnip moth). AIN34684.1

A0A088M9J3 [T]

Thioesterase-Ap {ECO:0000313|EMBL:AHH80648.1} Antheraea pernyi (Chinese oak silk moth). AHH80648.1

W5VH72 [T]

Putative palmitoyl-protein thioesterase {ECO:0000313|EMBL:AAN13045.1} Arabidopsis thaliana (Mouse-ear cress). AAN13045.1
AEE80048.1
AEE80049.1
BAH20058.1
CAB87871.1
NP_191593.1
NP_850728.1
Q9LY31 [T]

Putative palmitoyl-protein thioesterase {ECO:0000313|EMBL:AAK59537.1} Arabidopsis thaliana (Mouse-ear cress). AAK59537.1

Q93Y57 [T]

Palmitoyl-protein thioesterase-like {ECO:0000313|EMBL:AAM65342.1} Arabidopsis thaliana (Mouse-ear cress). AAM65342.1

Q8LAH5 [T]

Palmitoyl-protein thioesterase-like {ECO:0000313|EMBL:AAM63476.1} Arabidopsis thaliana (Mouse-ear cress). AAM63476.1

Q8LCP7 [T]

Putative uncharacterized protein At4g17480 {ECO:0000313|EMBL:AAO42200.1} Arabidopsis thaliana (Mouse-ear cress). AAO42200.1
AAO63889.1
AEE83898.1
NP_193478.1
Q84JI7 [T]

Putative uncharacterized protein At4g17483 {ECO:0000313|EMBL:AAM91633.1} Arabidopsis thaliana (Mouse-ear cress). AAM91633.1
AEE83899.1
NP_193479.1
Q8L7H5 [T]

Palmitoyl-protein thioesterase-like {ECO:0000313|EMBL:BAA97167.1} Arabidopsis thaliana (Mouse-ear cress). AAV97798.1
AAW38984.1
AED95499.1
BAA97167.1
NP_199544.1
Q9LVS6 [T]

Putative palmitoyl-protein thioesterase {ECO:0000313|EMBL:AAO42190.1} Arabidopsis thaliana (Mouse-ear cress). AAO42190.1

Q84W68 [T]

Putative palmitoyl-protein thioesterase {ECO:0000313|EMBL:AEE83895.1} Arabidopsis thaliana (Mouse-ear cress). AAY25412.1
AEE83895.1
AEE83896.1
AEE83897.1
NP_001190752.1
NP_001190753.1
NP_193477.1
Q501G7 [T]

Palmitoyl-protein thioesterase-like {ECO:0000313|EMBL:AAM61704.1} Arabidopsis thaliana (Mouse-ear cress). AAM61704.1

Q8LEY5 [T]

Putative uncharacterized protein At5g47350 {ECO:0000313|EMBL:AAM13072.1} Arabidopsis thaliana (Mouse-ear cress). AAM13072.1
AAM91172.1
AED95501.1
BAA97169.1
NP_199546.1
Q9LVS4 [T]

Putative uncharacterized protein At4g17483 {ECO:0000313|EMBL:BAD43298.1} Arabidopsis thaliana (Mouse-ear cress). BAD43298.1

Q681T2 [T]

Palmitoyl-protein hydrolase 1 3.1.2.22
Bos taurus (Bovine). AAA59357.1
AAI34480.1
NP_776579.1
P45478 [P]
P45478.1
1EH5
1EI9
1EXW
Lysosomal thioesterase PPT2 3.1.2.-
Bos taurus (Bovine). AAI16123.1
AAX46676.1
NP_001030395.2
XP_005223714.1
Q1JQA0 [T]
Q1JQA0.1

Palmitoyl-protein hydrolase 1 3.1.2.22
Caenorhabditis elegans. AAU01161.1
CCD71207.2
NP_504684.2
Q20390 [T]
Q20390.2

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:ACO15203.1} Caligus clemensi (Sea louse). ACO15203.1

C1C1Q0 [T]

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:ACO10282.1} Caligus rogercresseyi (Sea louse). ACO10282.1

C1BMM9 [T]

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:ACO10700.1} Caligus rogercresseyi (Sea louse). ACO10700.1

C1BNU7 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000034569} Canis familiaris (Dog) (Canis lupus familiaris). CAI44937.1
NP_001010944.1
Q5JZR0 [T]

Uncharacterized protein {ECO:0000313|EMBL:AEE62011.1} Dendroctonus ponderosae (Mountain pine beetle). AEE62011.1

J3JUY4 [T]

Uncharacterized protein {ECO:0000313|EMBL:AEE61897.1} Dendroctonus ponderosae (Mountain pine beetle). AEE61897.1
ENN80889.1
ERL85730.1

J3JUM0 [T]

MIP09280p {ECO:0000313|EMBL:ACN81347.1} Drosophila melanogaster (Fruit fly). ACN81347.1

C0PV70 [T]

Palmitoyl-protein hydrolase 1 3.1.2.22
Drosophila melanogaster (Fruit fly). AAF46403.2
AAM48346.1
AAM49613.1
AAS93752.1
AGS83394.1
AHN59495.1
NP_001285024.1
NP_727284.1
Q9W3C7 [P]
Q9W3C7.2
S5WMX5 [T]

Lysosomal thioesterase PPT2 homolog 3.1.2.-
Drosophila melanogaster (Fruit fly). AAF53092.1
AAL28270.1
AAX33594.1
ACL88313.1
ACL92410.1
NP_609500.1
Q9VKH6 [T]
Q9VKH6.1

Palmitoyl protein thioesterase {ECO:0000313|EMBL:ACO35364.1} Elaeis oleifera (American oil palm) (Corozo oleifera). ACO35364.1

C1K4P2 [T]

cDNA FLJ53673, highly similar to Palmitoyl-protein thioesterase 1 (EC 3.1.2.22) {ECO:0000313|EMBL:BAG63155.1} Homo sapiens (Human). BAG63155.1

B4DWU3 [T]

cDNA FLJ78536, highly similar to Homo sapiens inactive palmitoyl-protein thioesterase-2i (PPT2) mRNA {ECO:0000313|EMBL:BAF83162.1} Homo sapiens (Human). BAF83162.1

A8K358 [T]

Palmitoyl-protein hydrolase 1 3.1.2.22
Homo sapiens (Human). AAA85337.1
AAB06236.1
AAB72224.1
AAH08426.1
ADQ31900.1
AIC49464.1
BAG35214.1
BAG63586.1
CAG46850.1
CAI11025.1
EAX07237.1
EAX07238.1
NP_000301.1
NP_001136076.1
P50897 [P]
P50897-1
P50897-2
P50897.1
3GRO
HCG1999928, isoform CRA_a {ECO:0000313|EMBL:EAX03592.1} 3.1.2.-
Homo sapiens (Human). AAB47495.1
AAB80730.1
AAB80731.1
AAH01355.1
ACE86903.1
ACE87590.1
BAF85418.1
CAB46981.1
CAB53659.1
CAG38577.1
CAI17424.1
CAI17426.2
CAI18342.1
CAI18344.1
CAI41763.1
CAI41797.1
CAI41798.1
CAI41799.1
CAM24823.1
CAM24825.1
CAM25714.1
CAM26213.1
CAM26215.1
CAM26216.1
CAM26218.1
CAQ06588.1
CAQ06590.1
CAQ09561.1
CAQ09617.1
CAQ09619.1
CAQ10692.1
CAQ10694.1
EAX03591.1
EAX03592.1
EAX03593.1
EAX03594.1
EAX03595.1
EAX03596.1
EAX03597.1
NP_001191032.1
NP_005146.4
A0A024RCQ8
Q9UMR5 [P]
Q9UMR5-1
Q9UMR5.4
1PJA
Uncharacterized protein {ECO:0000313|EnsemblPlants:MLOC_72732.3} Hordeum vulgare var. distichum (Domesticated barley). BAJ93710.1
BAK02099.1

F2DF39 [T]

Predicted protein {ECO:0000313|EMBL:BAJ88880.1} Hordeum vulgare var. distichum (Domesticated barley). BAJ88880.1

F2D1A9 [T]

Predicted protein {ECO:0000313|EMBL:BAJ93249.1} Hordeum vulgare var. distichum (Domesticated barley). BAJ93249.1

F2DDS8 [T]

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:ADD38500.1} Lepeophtheirus salmonis (Salmon louse). ADD38500.1

D3PIW4 [T]

Uncharacterized protein {ECO:0000313|EMBL:AFK40085.1} Lotus japonicus (Lotus corniculatus var. japonicus). AFK40085.1

I3SIJ3 [T]

Uncharacterized protein {ECO:0000313|EMBL:AFK42463.1} Lotus japonicus (Lotus corniculatus var. japonicus). AFK42463.1

I3SQC1 [T]

32.2 kDa salivary protein {ECO:0000313|EMBL:AAS16918.1} Lutzomyia longipalpis (Sand fly). AAS16918.1

Q5WPS7 [T]

Palmitoyl-protein hydrolase 1 3.1.2.22
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). BAC20604.1
NP_001270850.1
Q8HXW6 [T]
Q8HXW6.1

Macaca fascicularis brain cDNA clone: QmoA-10094, similar to human palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis,neuronal 1, infantile) (PPT1), mRNA, RefSeq: NM_000310.1 {ECO:0000313|EMBL:BAE87344.1} Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). BAE87344.1

I7GJP0 [T]

Brain cDNA, clone: QtrA-13985, similar to human palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis,neuronal 1, infantile) (PPT1) {ECO:0000313|EMBL:BAE01719.1} Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). BAE01719.1

Q4R5A6 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000012042} Macaca mulatta (Rhesus macaque).
NP_001248261.1
F7HMC7 [T]

Putative palmitoyl-protein thioesterase {ECO:0000313|EMBL:ABM55661.1} Maconellicoccus hirsutus (Pink hibiscus mealybug). ABM55661.1

A2I492 [T]

Uncharacterized protein {ECO:0000313|EMBL:AFK44258.1} Medicago truncatula (Barrel medic) (Medicago tribuloides). AFK44258.1
KEH21572.1

I3SVG6 [T]

Uncharacterized protein {ECO:0000313|EMBL:AFK37690.1} Medicago truncatula (Barrel medic) (Medicago tribuloides). AFK37690.1

I3SBP8 [T]

Lysosomal thioesterase PPT2 3.1.2.-
Mus musculus (Mouse). AAB82011.1
AAH13462.1
AAH52330.1
EDL26784.1
EDL26785.1
EDL26787.1
EDL26788.1
NP_001289322.1
NP_001289323.1
NP_001289324.1
NP_001289325.1
NP_062314.1
XP_006524701.1
XP_006525484.1
XP_006536732.1
XP_006537463.1
O35448 [T]
O35448.1

Palmitoyl-protein hydrolase 1 3.1.2.22
Mus musculus (Mouse). AAC25398.1
AAD25224.1
AAI41456.1
AAI48715.1
AAL37403.1
AAL37404.1
BAE30117.1
BAE31248.1
BAE31611.1
BAE31725.1
BAE41238.1
EDL30401.1
NP_032943.2
O88531 [T]
O88531.2
Q3TEL0
Q3U6J9
Q3U6W3
Q8VBX5

Uncharacterized protein {ECO:0000313|EMBL:EEC67448.1} Oryza sativa subsp. indica (Rice). ABB47987.1
BAF27234.2
BAG92988.1
EEC67448.1
EEE51405.1
NP_001065397.2
B8BI74
Q336S3 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:EEC74327.1} Oryza sativa subsp. indica (Rice). ABF93475.1
BAF10564.1
BAH00197.1
EEC74327.1
EEE58142.1
NP_001048650.1
B8AL03
Q10T53 [T]

Palmitoyl-protein thioesterase 2 {ECO:0000313|EMBL:JAA28874.1} Pan troglodytes (Chimpanzee).
XP_003311242.1
K7CR34 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000001012} Pan troglodytes (Chimpanzee).
XP_001172215.1
H2PYR6 [T]

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:BAM18109.1} Papilio xuthus (Asian swallowtail butterfly). BAM18109.1

I4DJL9 [T]

Palmitoyl-protein thioesterase {ECO:0000313|EMBL:AFY98638.1} Phaseolus vulgaris (Kidney bean) (French bean). AFY98638.1

K9USX6 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:ABK23278.1} Picea sitchensis (Sitka spruce) (Pinus sitchensis). ABK23278.1

A9NRL7 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000001728} Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). CAH93135.1

Q5R531 [T]

Putative uncharacterized protein DKFZp459C1220 {ECO:0000313|EMBL:CAI29673.1} Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). CAI29673.1
NP_001127688.1
Q5NVJ0 [T]

Uncharacterized protein {ECO:0000313|EMBL:ERP65555.1} Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa). ABK93872.1
ERP65555.1
XP_006368986.1
A9PBW9 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:ABK93080.1} Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa). ABK93080.1

A9P9M7 [T]

Palmitoyl-protein hydrolase 1 3.1.2.22
Rattus norvegicus (Rat). AAA59358.1
AAI26090.1
EDL80359.1
EDL80360.1
NP_071947.1
P45479 [P]
P45479.1

Lysosomal thioesterase PPT2 3.1.2.-
Rattus norvegicus (Rat). AAC16003.1
AAC19366.1
AAH62023.1
CAE83963.1
EDL83408.1
EDL83409.1
EDL83410.1
NP_062240.1
XP_006256080.1
XP_006256081.1
XP_006256082.1
XP_006256084.1
XP_006256085.1
XP_008770984.1
O70489 [T]
O70489-1
O70489.1

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:CAX69665.1} 3.1.2.22 {ECO:0000313|EMBL:CAX69665.1}
Schistosoma japonicum (Blood fluke). CAX69665.1

C1L4N7 [T]

SJCHGC04223 protein {ECO:0000313|EMBL:AAW26730.1} Schistosoma japonicum (Blood fluke). AAW26730.1

Q5DBS6 [T]

Dolichyl pyrophosphate phosphatase {ECO:0000250|UniProtKB:P53223, ECO:0000303|PubMed:15075260} 3.1.2.22
3.6.1.43
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). CAA19178.2
NP_595325.2
O59747 [P]
O59747.2

Palmitoyl protein thioesterase {ECO:0000313|EMBL:CCQ18670.1} Sycon ciliatum. CCQ18670.1

M1XMU0 [T]

Putative palmitoyl-protein thioesterase {ECO:0000313|EMBL:AAR92492.1} Tropaeolum majus (Common nasturtium) (Indian cress). AAR92492.1

Q6R749 [T]

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:ACD11363.1} Wuchereria bancrofti. ACD11363.1

B2ZFM4 [T]

Lysosomal thioesterase PPT2-B 3.1.2.-
Xenopus laevis (African clawed frog). AAH73363.1
NP_001085801.1
Q6GNY7 [T]
Q6GNY7.1

Uncharacterized protein {ECO:0000313|EMBL:ACN33930.1, ECO:0000313|EnsemblPlants:GRMZM2G374779_P01} Zea mays (Maize). ACN33930.1
NP_001232846.1
XP_008651020.1
C0PFG4 [T]

Palmitoyl-protein thioesterase 1 {ECO:0000313|EMBL:ACG35638.1} Zea mays (Maize). ACG35638.1

B6TEV5 [T]

Uncharacterized protein {ECO:0000313|EMBL:ACF82561.1, ECO:0000313|EnsemblPlants:GRMZM2G093880_P01} Zea mays (Maize). ACF82561.1
ACG33007.1
ACR37702.1
AFW87851.1
NP_001136761.1
XP_008658170.1
B4FKB8 [T]

Uncharacterized protein {ECO:0000313|EMBL:ACF80685.1, ECO:0000313|EnsemblPlants:GRMZM2G374779_P02} Zea mays (Maize). ACF80685.1
NP_001132014.1
B4FEZ2 [T]