ThYme: Thioester-active Enzymes

Family TE2

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Fold α/β- Hydrolase
Names of enzymes and/or genes present 1. Acyl-CoA thioesterase (Acot) 1-6
2. Bile acid-CoA amino acid N-acyltransferase (BAT) thioesterase
EC numbers 3.1.2- (thioester hydrolase)
3.1.2.2 (palmitoyl-CoA hydrolase)
2.3.1.65 (bile acid:amino acid N-acyltransferase)
Catalytic residues Ser, His, Asp
Notes

Palmitoyl-CoA hydrolysis, bile-acid-transfer activities

 

Numbers [P] (Evidence at Protein Level) = 14
[T] (Evidence at Transcript Level) = 17
PDBs = 2
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Long chain acyl-CoA thioesterase-like protein {ECO:0000313|EMBL:ABD04177.1} Anthopleura elegantissima (Sea anemone). ABD04177.1

Q2F6G5 [T]

ACOT2 protein {ECO:0000313|EMBL:AAI49742.1} Bos taurus (Bovine). AAI49742.1
NP_001095408.1
A6QQA9 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000003683} Bos taurus (Bovine). AAI42162.1
NP_001092411.2
A5PJL7 [T]

Acyl-CoA thioesterase 1 {ECO:0000313|EMBL:AAI27748.1} Homo sapiens (Human). AAI27748.1

A1L172 [T]

cDNA FLJ54503, highly similar to Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) {ECO:0000313|EMBL:BAG62528.1} Homo sapiens (Human). BAG62528.1

B4DV16 [T]

cDNA FLJ35812 fis, clone TESTI2006051, highly similar to Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) {ECO:0000313|EMBL:BAG52662.1} Homo sapiens (Human). BAG52662.1
XP_006720070.1
B3KSA0 [T]

Uncharacterized protein {ECO:0000313|EMBL:AAI44426.1} Homo sapiens (Human). AAI44426.1

B7ZMC1 [T]

Epididymis secretory sperm binding protein Li 188n {ECO:0000313|EMBL:ADU87641.1} 3.1.2.2
Homo sapiens (Human). AAI27749.1
AAI32890.1
AAI32892.1
AAI43043.1
AAZ31236.1
ADU87641.1
AIC53893.1
CAD61883.1
NP_001032238.1
E9KL42 [T]
Q86TX2 [P]
Q86TX2.1

ZAP128 3.1.2.2
Homo sapiens (Human). AAC42007.1
AAF97985.1
AAH04436.2
AAH06335.1
AAH06500.4
AAZ31237.1
BAA91989.1
BAD97355.1
NP_006812.3
P49753 [P]
P49753-1
P49753.6
3HLK
Peroxisomal long-chain acyl-CoA thioesterase Ib 3.1.2.2
Homo sapiens (Human). AAH31799.2
AAH90945.1
AAI17342.1
AAI17344.1
AIC52956.1
BAB71017.1
BAC04313.1
CAD62346.1
CAD62354.1
EAW81121.1
NP_689544.3
Q8N9L9 [P]
Q8N9L9.2
3K2I
Putative acyl-coenzyme A thioesterase 6 3.1.2.-
Homo sapiens (Human). AAI26379.1
AAI26381.1
AAZ31238.1
ADR82840.1
AIC53894.1
NP_001032239.1
Q3I5F7 [P]
Q3I5F7.1

Bile acid Coenzyme A: amino acid N-acyltransferase (Glycine N-choloyltransferase), isoform CRA_a {ECO:0000313|EMBL:EAW58945.1} 2.3.1.65
3.1.2.2
Homo sapiens (Human). AAC37550.1
AAH09567.1
AAI07425.1
CAG46716.1
CAH72995.1
EAW58943.1
EAW58945.1
NP_001121082.1
NP_001692.1
A0A024R155
Q14032 [P]
Q14032.1

Acyl-coenzyme A thioesterase 1 {ECO:0000313|EMBL:CDG69097.1} Hydra vulgaris (Hydra) (Hydra attenuata).
XP_002158086.2
T2MB03 [T]

Macaca fascicularis brain cDNA clone: QflA-22539, similar to human peroxisomal long-chain acyl-coA thioesterase (ZAP128), mRNA, RefSeq: NM_006821.3 {ECO:0000313|EMBL:BAE90496.1} Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). BAE90496.1
NP_001270861.1
I7GIT8 [T]

Brain cDNA, clone: QtrA-10238, similar to human peroxisomal long-chain acyl-coA thioesterase (ZAP128),mRNA, RefSeq: NM_006821.3 {ECO:0000313|EMBL:BAE01977.1} Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). BAE01977.1
NP_001277445.1
Q4R4J8 [T]

Peroxisomal long-chain acyl-CoA thioesterase 2 3.1.2.2
Mus musculus (Mouse). AAF13873.1
AAI38742.1
AAI38744.1
AAS75455.1
AAS75456.1
EDL02758.1
NP_599007.1
XP_006515571.1
XP_006515572.1
Q53YL1
Q9QYR7 [T]
Q9QYR7-1
Q9QYR7-2
Q9QYR7.1

Very-long-chain acyl-CoA thioesterase 3.1.2.2
Mus musculus (Mouse). AAF13871.1
AAH64469.1
BAE43095.1
EDL02755.1
NP_598949.3
Q6P2K2
Q9QYR9 [P]
Q9QYR9.2

Long chain acyl-CoA thioester hydrolase 3.1.2.2
Mus musculus (Mouse). AAF13870.1
AAH28261.1
CAA74327.1
NP_036136.1
O55137 [P]
O55137.1

Peroxisomal long-chain acyl-CoA thioesterase Ib 3.1.2.2
Mus musculus (Mouse). AAF13872.1
AAI13186.1
BAC32814.1
BAC34246.1
BAC38060.1
EDL02757.1
NP_599008.3
Q14DI6
Q8BWN8 [P]
Q8BWN8.1

Acyl-coenzyme A thioesterase 6 3.1.2.-
Mus musculus (Mouse). AAH02159.1
AAI39307.1
AAI39329.1
AAY45894.1
BAC30372.1
BAC33071.1
BAE22505.1
BAE37416.1
EDL02761.1
NP_766168.1
B2RTE4
Q32Q92 [P]
Q32Q92-1
Q32Q92.1

Acyl-coenzyme A amino acid N-acyltransferase 1 {ECO:0000303|PubMed:17116739} 2.3.1.-
Mus musculus (Mouse). ABE98441.1
CAM21766.1
CAM21767.1
EDL02321.1
NP_001158037.1
XP_006537905.1
XP_006537906.1
XP_011248303.1
XP_011248304.1
XP_011248305.1
XP_011248306.1
XP_011248307.1
A2AKK5 [P]
A2AKK5-1
A2AKK5.1

Acyl-coenzyme A amino acid N-acyltransferase 2 {ECO:0000303|Ref.1} 2.3.1.-
Mus musculus (Mouse). AAH10829.1
ACB55609.1
BAC34180.1
BAC34207.1
CAM27903.3
CAM27904.1
NP_663343.2
XP_006537789.1
XP_011248270.1
Q8BGG9 [T]
Q8BGG9-1
Q8BGG9.1

Long-chain fatty-acyl-CoA hydrolase 2.3.1.65
3.1.2.2
Mus musculus (Mouse). AAB58325.1
BAC25534.1
CAM21769.1
EDL02319.1
NP_031545.2
Q91X34 [P]
Q91X34.1

Peroxisomal acyl-coenzyme A thioester hydrolase Ic 3.1.2.2
Mus musculus (Mouse). AAS75457.1
AHA90858.1
NP_663419.3
Q6Q2Z6 [T]
Q6Q2Z6.2

Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000011062} Pan troglodytes (Chimpanzee).
XP_510048.2
H2Q8K3 [T]

Acyl-coenzyme a thioesterase 4 {ECO:0000313|EMBL:AHJ25805.1} Panthera tigris altaica (Siberian tiger). AHJ25805.1

W6FFA0 [T]

Long chain acyl-CoA thioester hydrolase 3.1.2.2
Rattus norvegicus (Rat). BAA32434.1
CAA70514.1
NP_112605.1
O88267 [P]
O88267.1

Very-long-chain acyl-CoA thioesterase 3.1.2.2
Rattus norvegicus (Rat). BAA32539.1
CAA70513.1

O55171 [P]
O55171.1

Acyl-coenzyme A amino acid N-acyltransferase 2 {ECO:0000250|UniProtKB:Q8BGG9} 2.3.1.-
Rattus norvegicus (Rat). AAH89827.1
NP_001014085.1
Q5FVR5 [T]
Q5FVR5.1

Long-chain fatty-acyl-CoA hydrolase 2.3.1.65
3.1.2.2
Rattus norvegicus (Rat). AAH88153.1
BAA07901.1
EDL78183.1
NP_058996.2
Q63276 [P]
Q63276.2