ThYme: Thioester-active Enzymes

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Names of enzymes and/or genes present 1. Acyl-CoA thioesterase (Acot7) or Brain acyl-CoA thioesterase (BACH)
2. Acot11 or Brown fat inducible thioesterase (BFIT) or Thioesterase superfamily member 1 (Them1)
3. Acot12 or cytosolic acyl-CoA thioesterase (CACH)
4. YciA
EC numbers 3.1.2.- (thioester hydrolase)
3.1.2.1 (acetyl-CoA hydrolase)
3.1.2.2 (palmitoyl-CoA hydrolase)
3.1.2.20 (acyl-CoA hydrolase)
Catalytic residues Asn, Asp
Notes

1. BACH enzymes are expressed mainly in brain tissue and act on C8 to C18 acyl-CoA chains.
2. Them1 enzymes act on medium to long chain fatty acids.
3. YciA enzymes are known to act on butyryl, hexanoyl, lauroyl and palmitoyl-CoA substrates.
 

Numbers [P] (Evidence at Protein Level) = 8
[T] (Evidence at Transcript Level) = 11
PDBs = 9
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Uncharacterized acyl-CoA thioester hydrolase HI_0827 3.1.2.-
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). AAC22485.1
AIB46434.1
EDJ93623.1
EDK07923.1
EDK14310.1
EEP48099.1
EEW77136.1
KIP50552.1
NP_438987.1
WP_005655643.1
A4N7N5
A4NET9
A4NX53
C4F4I6
C9MFM0
P44886 [P]
P44886.1
1YLI
3BJK
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000028254} Bos taurus (Bovine). AAI18302.1
NP_001069150.2
F6Q5U0
Q148I4 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSCJAP00000028647} Callithrix jacchus (White-tufted-ear marmoset).
XP_002750937.2
F6W6K5 [T]

Cytosolic acyl coenzyme A thioester hydrolase-like protein {ECO:0000313|EMBL:ABQ22382.1} Callithrix jacchus (White-tufted-ear marmoset). ABQ22382.1

A6MJZ1 [T]

Brown fat-inducible thioesterase 3.1.2.-
Homo sapiens (Human). AAH01517.1
AAH93844.1
AAH93846.1
AAL40937.1
AAL40938.1
BAA31682.1
BAB14734.1
BAD97290.1
CAH71611.1
CAH71612.1
EAX06682.1
EAX06683.1
EAX06684.1
NP_056362.1
NP_671517.1
Q8WXI4 [P]
Q8WXI4-1
Q8WXI4-2
Q8WXI4.1

cDNA FLJ60167, highly similar to Cytosolic acyl coenzyme A thioester hydrolase(EC 3.1.2.2) {ECO:0000313|EMBL:BAG62482.1} Homo sapiens (Human). BAG62482.1

B4DUX0 [T]

START domain-containing protein 15 3.1.2.1
Homo sapiens (Human). AAH75010.1
AAH75011.1
AAH89437.1
AIC53081.1
BAB84022.1
BAG53821.1
EAW95875.1
NP_570123.1
Q8WYK0 [P]
Q8WYK0-1
Q8WYK0.1
3B7K
4MOB
4MOC
Long chain acyl-CoA thioester hydrolase 3.1.2.2
Homo sapiens (Human). AAB61211.1
AAH17365.2
AAP35534.1
BAA24350.1
BAC20174.1
BAC20175.1
BAC20176.1
BAC20177.1
BAC20178.1
BAF82261.1
BAF82786.1
BAF84272.1
BAF84891.1
BAG51874.1
CAI19435.1
CAI19440.1
CAI19442.1
CAI19443.1
CAI19774.1
CAI19777.1
CAI19778.1
CAI19779.1
EAW71528.1
EAW71529.1
EAW71530.1
EAW71531.1
NP_009205.3
NP_863654.1
NP_863655.1
NP_863656.1
O00154 [P]
O00154-1
O00154-5
O00154-6
O00154-7
O00154.3
2QQ2
Testis cDNA, clone: QtsA-15551, similar to human brain acyl-CoA hydrolase (BACH), transcript varianthBACHa {ECO:0000313|EMBL:BAE00986.1} Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). BAE00986.1

Q4R7D6 [T]

Brown fat-inducible thioesterase 3.1.2.-
Mus musculus (Mouse). AAH42492.1
AAL40939.1
BAC27464.1
BAC33416.1
BAC34942.1
EDL30802.1
NP_079866.2
Q543P6
Q8VHQ9 [T]
Q8VHQ9.1

Cytoplasmic acetyl-CoA hydrolase 1 3.1.2.1
Mus musculus (Mouse). AAH25852.1
AAI32051.1
AAI37997.1
BAB23658.1
BAB84021.1
BAC28775.1
EDL00967.1
NP_083066.1
A2RSC2
Q9DBK0 [P]
Q9DBK0.1

Long chain acyl-CoA thioester hydrolase 3.1.2.2
Mus musculus (Mouse). AAH13507.1
BAB61731.1
BAC20217.1
BAC20218.1
BAD91166.1
BAE31092.1
CAM19695.1
CAM19696.1
CAM19698.1
CAM23900.1
CAM23901.1
CAM23903.1
CAM26444.1
CAM26445.1
CAM26446.1
EDL14929.1
NP_001139529.1
NP_001139530.1
NP_579926.2
E9PYH2
Q91V12 [P]
Q91V12-3
Q91V12-4
Q91V12.2
2Q2B
2V1O
Acyl-CoA thioesterase 11 {ECO:0000313|EMBL:JAA35631.1} Pan troglodytes (Chimpanzee).
XP_001152786.1
K7BZE0 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000000158} Pan troglodytes (Chimpanzee).
XP_001156114.1
H2PXW7 [T]

Putative uncharacterized protein DKFZp469E1816 {ECO:0000313|EMBL:CAH89858.1} Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). CAH89858.1
NP_001127204.1
Q5REE9 [T]

Putative uncharacterized protein DKFZp459D219 {ECO:0000313|EMBL:CAH91829.1} Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). CAH91829.1

Q5R8T1 [T]

Putative uncharacterized protein DKFZp468I1112 {ECO:0000313|EMBL:CAH90361.1} Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). CAH90361.1
NP_001126057.1
Q5RCZ6 [T]

Cytoplasmic acetyl-CoA hydrolase 1 3.1.2.1
Rattus norvegicus (Rat). BAB39852.1
NP_570103.1
Q99NB7 [P]
Q99NB7.1

MTE-II 3.1.2.2
Rattus norvegicus (Rat). AAC53202.1
AAH87716.1
BAA19626.1
BAA19627.2
CAA70512.1
EDL81226.1
EDL81227.1
NP_001139533.1
NP_037346.2
F8WG67
Q64559 [P]
Q64559-2
Q64559.4