ThYme: Thioester-active Enzymes

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Names of enzymes and/or genes present 1. Acyl-CoA thioesterase (Acot7) or Brain acyl-CoA thioesterase (BACH)
2. Acot11 or Brown fat inducible thioesterase (BFIT) or Thioesterase superfamily member 1 (Them1)
3. Acot12 or cytosolic acyl-CoA thioesterase (CACH)
4. YciA
EC numbers 3.1.2.- (thioester hydrolase)
3.1.2.1 (acetyl-CoA hydrolase)
3.1.2.2 (palmitoyl-CoA hydrolase)
3.1.2.20 (acyl-CoA hydrolase)
Catalytic residues Asn, Asp
Notes

1. BACH enzymes are expressed mainly in brain tissue and act on C8 to C18 acyl-CoA chains.
2. Them1 enzymes act on medium to long chain fatty acids.
3. YciA enzymes are known to act on butyryl, hexanoyl, lauroyl and palmitoyl-CoA substrates.
 

Numbers [P] (Evidence at Protein Level) = 8
[T] (Evidence at Transcript Level) = 11
PDBs = 9
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Hydrolase {ECO:0000313|EMBL:AHK55440.1} Campylobacter jejuni subsp. jejuni NCTC 11168-mcK12E5. AGV47766.1
AGV49529.1
AGV51204.1
AGV56696.1
AHK52109.1
AHK53774.1
AHK55440.1
AHK57105.1
AHK58769.1
AJA55080.1
AJK72750.1
AJK82896.1
AJK84731.1
CAL35035.1
CCK67012.1
EAQ56174.1
EAQ95290.1
EFV09024.1
EIB18483.1
EIB34876.1
EIB67636.1
EIB73457.1
EIB80100.1
EIB83342.1
EIB83977.1
WP_002853315.1
YP_002344313.1
A0A0B6V1C9
Q0P9Y4
W8INA5
W8ISS7
W8J6R7
W8JG21
W8JKP1
3D6L
Uncharacterized acyl-CoA thioester hydrolase HI_0827 3.1.2.-
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). AAC22485.1
AIB46434.1
EDJ93623.1
EDK07923.1
EDK14310.1
EEP48099.1
EEW77136.1
KIP50552.1
NP_438987.1
WP_005655643.1
A4N7N5
A4NET9
A4NX53
C4F4I6
C9MFM0
P44886 [P]
P44886.1
1YLI
3BJK
Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
START domain-containing protein 15 3.1.2.1
Homo sapiens (Human). AAH75010.1
AAH75011.1
AAH89437.1
AIC53081.1
BAB84022.1
BAG53821.1
EAW95875.1
NP_570123.1
Q8WYK0 [P]
Q8WYK0-1
Q8WYK0.1
3B7K
4MOB
4MOC
Long chain acyl-CoA thioester hydrolase 3.1.2.2
Homo sapiens (Human). AAB61211.1
AAH17365.2
AAP35534.1
BAA24350.1
BAC20174.1
BAC20175.1
BAC20176.1
BAC20177.1
BAC20178.1
BAF82261.1
BAF82786.1
BAF84272.1
BAF84891.1
BAG51874.1
CAI19435.1
CAI19440.1
CAI19442.1
CAI19443.1
CAI19774.1
CAI19777.1
CAI19778.1
CAI19779.1
EAW71528.1
EAW71529.1
EAW71530.1
EAW71531.1
NP_009205.3
NP_863654.1
NP_863655.1
NP_863656.1
O00154 [P]
O00154-1
O00154-5
O00154-6
O00154-7
O00154.3
2QQ2
Long chain acyl-CoA thioester hydrolase 3.1.2.2
Mus musculus (Mouse). AAH13507.1
BAB61731.1
BAC20217.1
BAC20218.1
BAD91166.1
BAE31092.1
CAM19695.1
CAM19696.1
CAM19698.1
CAM23900.1
CAM23901.1
CAM23903.1
CAM26444.1
CAM26445.1
CAM26446.1
EDL14929.1
NP_001139529.1
NP_001139530.1
NP_579926.2
E9PYH2
Q91V12 [P]
Q91V12-3
Q91V12-4
Q91V12.2
2Q2B
2V1O