ThYme: Thioester-active Enzymes

Family TE22

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Fold α/β-Hydrolase
Names of enzymes and/or genes present 1. S-formylglutathione hydrolase
2. Esterase A (acetyl esterase)
3. Esterase D (carboxyesterase)
EC numbers 3.1.2.12 (S-formylglutathione hydrolase)
3.1.1.1 (carboxylesterase)
3.1.1.6 (acetylesterase)
Catalytic residues Ser, His, Asp
Notes

Hydrolysis of S-formylglutathione into formate and glutathione.


 

Numbers [P] (Evidence at Protein Level) = 11
[T] (Evidence at Transcript Level) = 49
PDBs = 11
Bacteria
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
S-formylglutathione hydrolase {ECO:0000313|EMBL:EIQ45913.1} 3.1.2.12
3.1.2.12 {ECO:0000313|EMBL:EIQ45913.1}
Escherichia coli 3-073-06_S1_C2. AAA60510.1
AAC75215.1
ABV06569.1
ACA77156.1
ACB03318.1
ACZ37325.1
ACZ37326.1
ACZ37327.1
ACZ37328.1
ACZ37330.1
ACZ37331.1
ACZ37332.1
AJH10882.1
BAE76631.1
CCQ29541.2
CDK84677.1
CDL27534.1
CDP70806.1
CDU37997.1
CDY59602.1
CDZ20976.1
CEE03675.1
EFI88663.1
EFK25201.1
EFK49369.1
EFK92277.1
EFZ57449.1
EGB89842.1
EGI11797.1
EGI20508.1
EGU97661.1
EGW93969.1
EHV57490.1
EHW16382.1
EIH25207.1
EII48883.1
EJE79969.1
EKJ83033.1
ELC07925.1
ELC59355.1
ELD99001.1
ELF08596.1
ELI37844.1
EMV57826.1
EMV58138.1
EMW79484.1
EMX20028.1
EMX30974.1
EMX47989.1
EMX86541.1
ENA07260.1
ENA31176.1
ENA39337.1
ENB27439.1
ENC91096.1
END58836.1
END91526.1
ENG96676.1
ENH02142.1
ENH08579.1
EOU58572.1
EOV12003.1
EOV18892.1
EOV78298.1
EOW06496.1
EOW13199.1
EOW18644.1
EOW22676.1
EOW45911.1
EQW92933.1
EQX51392.1
EQY59890.1
EQZ36907.1
ERB06833.1
ERB27551.1
ESA31194.1
ESA60666.1
ESA77919.1
ESA91811.1
ESD28006.1
ESD68093.1
ESD99855.1
ESP08147.1
ETS28043.1
EYE24292.1
EZD97010.1
EZE29217.1
EZJ74423.1
KDU33124.1
KDU55905.1
KDU64509.1
KDV31096.1
KDX89434.1
KDY24234.1
KDY55499.1
KDY58286.1
KDY59306.1
KDY92240.1
KDY99222.1
KDZ19449.1
KDZ41666.1
KDZ67412.1
KEJ50056.1
KEJ67706.1
KEL28833.1
KEN48080.1
KEN89763.1
KEN97248.1
KEO10167.1
KEO23269.1
KGM60633.1
KGM70533.1
KGM74852.1
KGM82135.1
KGM83843.1
KHD36422.1
KHD54313.1
KHI93093.1
KIG80831.1
KIH05654.1
KII06133.1
KIN86965.1
NP_416659.1
YP_001458952.1
YP_001724483.1
YP_001731096.1
YP_490393.1
A0A017LLE3
A0A027ZDP5
A0A028C0P7
A0A029KM55
A0A069XT44
A0A069Z8F0
A0A070CQQ5
A0A070YG01
A0A071AG75
A0A071C2U8
A0A071CK48
A0A071DN19
A0A071F9N9
A0A073GS11
A0A073TJP5
A0A074HSD2
A0A074IJC0
A0A079BB20
A0A079DN48
A0A079FGN2
A0A079FKK3
A0A079HDH3
A0A079XY74
A0A080EKN7
A0A080GQX2
A0A080HZM7
A0A0A0FE39
A8A215
B1IYB5
B1X7P2
D1MDQ0
D7ZV58
D8BXG6
D8ESS4
E1HIG8
E7ICY8
E9TA66
F4SMT2
F4TIC4
F8XC31
G2AWR4
H4ULB8
H4ZYN9
I2SWN6
I2XIR3
K4WJB0
K5CPM3
L2V0L0
L2Z6V6
L3KKW7
L3UIE5
L4WD34
M8SMD6
M8SYF6
M9CGJ5
M9FCG3
M9GEF8
M9HT09
M9JXA4
N2H2Y6
N2J5C3
N2JIV3
N2RW64
N3FHX4
N3KYM7
N3NMF7
N4NEM1
N4NVA1
N4P634
P33018 [P]
S0VAS1
S0ZMC7
S1A1M0
S1F3S6
S1HGJ1
S1HZU3
S1IFV8
S1ISE7
S1KQY9
T8TDS9
T8X3K8
T9H4N5
T9M4L0
U0BA96
U0D050
U9VEZ5
U9XGZ2
U9YTX3
V0A239
V0U7R0
V0Y6G4
V1A632
V4BQL1
W1BXE0
W1EZH0
W3UWU3

S-formylglutathione hydrolase {ECO:0000313|EMBL:CDZ19219.1} 3.1.2.12
3.1.2.12 {ECO:0000313|EMBL:CDZ19219.1}
Escherichia coli. AAB18080.1
AAC73458.1
ACB01488.1
ACR64369.1
ACX40875.1
AIF35738.1
AIN30861.1
AIZ30006.1
AIZ53330.1
AIZ92495.1
AJD73946.1
AJD73956.1
BAE76137.1
BAJ42198.1
BAL37585.1
CDJ70832.1
CDY55303.1
CDZ19219.1
EGU24924.1
EGV46560.1
EIE35370.1
EMD15215.1
KGA87403.1
KGL67866.1
NP_414889.1
WP_000419081.1
YP_001729266.1
YP_488649.1
A0A090HRD5
A0A0B4ZS69
B1XEU8
B1XEU8.1
C4ZTB9
C9QQS3
P51025 [P]
P51025.2

S-formylglutathione hydrolase {ECO:0000313|EMBL:EEW76363.1} 3.1.2.12
Haemophilus influenzae RdAW. AAC21853.1
EEW76363.1
NP_438352.1
WP_005694102.1
C9MII0
P44556 [P]
P44556.1

Esterase APC40077 {ECO:0000313|PDB:3I6Y} 3.1.1.2 {ECO:0000313|PDB:3I6Y}
Oleispira antarctica.

D0VWZ4 [P]
3I6Y
3S8Y
S-formylglutathione hydrolase 3.1.2.12
Paracoccus denitrificans (strain Pd 1222). AAC44554.1
ABL68136.1
ACR45017.1
ACR45022.1
WP_011746369.1
YP_913832.1
A1AXZ2 [P]
A1AXZ2.1

Eukaryota
Sequence EC Number Organism GenBank ID RefSeq UniProt PDB
Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ACYPI002273-PA} Acyrthosiphon pisum (Pea aphid). BAH70623.1
NP_001156105.1
XP_008181724.1
XP_008181725.1
XP_008181726.1
XP_008181727.1
C4WRV3 [T]

Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ACYPI003128-PA} Acyrthosiphon pisum (Pea aphid). BAH71603.1
NP_001155509.1
C4WUN3 [T]

Esterase D 3.1.2.12
Arabidopsis thaliana (Mouse-ear cress). AAB84335.1
AAK55678.1
AAK73263.1
AAL38594.1
AAM65175.1
AEC09995.1
CAC87877.1
NP_181684.1
Q8LAS8 [P]
Q8LAS8.2

S-formylglutathione hydrolase {ECO:0000313|EMBL:ADY47680.1} Ascaris suum (Pig roundworm) (Ascaris lumbricoides). ERG84703.1

F1LC26 [T]

Esterase D 3.1.2.12
Bos taurus (Bovine). AAI23462.1
NP_001069533.1
XP_005213718.1
XP_005213719.1
Q08E20 [T]
Q08E20.1

S-formylglutathione hydrolase {ECO:0000313|EMBL:JAB35079.1} Callithrix jacchus (White-tufted-ear marmoset).
XP_002742723.1
XP_008990396.1
U3DYQ8 [T]

S-formylglutathione hydrolase {ECO:0000313|EMBL:JAC05132.1} Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
XP_004537288.1
W8CAC1 [T]

Esterase {ECO:0000313|EMBL:EDP00170.1} 3.1.1.1 {ECO:0000313|EMBL:EDP00170.1}
Chlamydomonas reinhardtii (Chlamydomonas smithii). EDP00170.1
XP_001697508.1
A8J7F8 [P]

Uncharacterized protein {ECO:0000313|EMBL:AEE63454.1} Dendroctonus ponderosae (Mountain pine beetle). AEE63454.1

J3JZ16 [T]

AT20328p {ECO:0000313|EMBL:ACT88126.1} Drosophila melanogaster (Fruit fly). ACT88126.1

C6SUZ3 [T]

GH03475p {ECO:0000313|EMBL:AAM50589.1} 3.1.1.- {ECO:0000313|EMBL:AAF55741.1}
3.1.1.1 {ECO:0000313|EMBL:AAF55741.1}
3.1.2.12 {ECO:0000313|EMBL:AAF55741.1}
Drosophila melanogaster (Fruit fly). AAF55741.1
AAM50589.1
NP_650864.1
Q9VDP9 [T]

Putative esterase D {ECO:0000313|EMBL:AAF34769.1} Euphorbia esula (Leafy spurge). AAF34769.1

Q9M5M3 [T]

Esterase {ECO:0000313|EMBL:ADY17231.1} 3.1.1.6 {ECO:0000313|EMBL:ADY17231.1}
Geomyces sp. P7. ADY17231.1

F1DI25 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:ACU19052.1} Glycine max (Soybean) (Glycine hispida). ACU19052.1

C6TB50 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:ACU18661.1} Glycine max (Soybean) (Glycine hispida). ACU18661.1

C6TA09 [T]

S-formylglutathione hydrolase {ECO:0000313|EMBL:ACJ11734.1} Gossypium hirsutum (Upland cotton) (Gossypium mexicanum). ACJ11734.1

D2D314 [T]

Methylumbelliferyl-acetate deacetylase 3.1.1.56
3.1.2.12
Homo sapiens (Human). AAA52408.1
AAC06298.1
AAC99788.1
AAH01169.1
AAP35708.1
AAX32313.1
AAX32314.1
AIC54360.1
CAI12225.1
CAI12226.1
CAI12228.1
EAX08768.1
NP_001975.1
XP_005266335.1
XP_011533256.1
P10768 [P]
P10768.2
3FCX
Predicted protein {ECO:0000313|EMBL:BAJ88717.1} Hordeum vulgare var. distichum (Domesticated barley). BAJ88717.1
BAJ97075.1

F2D0U6 [T]

Predicted protein {ECO:0000313|EMBL:BAJ99080.1} Hordeum vulgare var. distichum (Domesticated barley). BAJ99080.1

F2DVF9 [T]

Predicted protein {ECO:0000313|EMBL:BAJ85049.1} Hordeum vulgare var. distichum (Domesticated barley). BAJ85049.1

F2CQC8 [T]

S-formylglutathione hydrolase {ECO:0000313|EMBL:ADD24366.1} Lepeophtheirus salmonis (Salmon louse). ADD24366.1

D3PGH0 [T]

Putative esterase Est7548 {ECO:0000313|EMBL:ABK20171.1} Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora decemlineata). ABK20171.1

A0FKG8 [T]

S-formylaldehyde hydrolase {ECO:0000313|EMBL:AEA38530.1} Linum usitatissimum (Flax) (Linum humile). AEA38530.1

F2YJ67 [T]

Uncharacterized protein {ECO:0000313|EMBL:AFK39449.1} Lotus japonicus (Lotus corniculatus var. japonicus). AFK39449.1

I3SGQ7 [T]

Uncharacterized protein {ECO:0000313|EMBL:AFK43696.1} Lotus japonicus (Lotus corniculatus var. japonicus). AFK43696.1

I3STV4 [T]

Macaca fascicularis brain cDNA clone: QtrA-16406, similar to human esterase D/formylglutathione hydrolase (ESD), mRNA, RefSeq: NM_001984.1 {ECO:0000313|EMBL:BAE91433.1} Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). BAE91433.1

I7GNM2 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000005628} Macaca mulatta (Rhesus macaque).
NP_001244408.1
F6Z3Y0 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:ACJ84789.1} Medicago truncatula (Barrel medic) (Medicago tribuloides). ACJ84789.1

B7FJ60 [T]

Uncharacterized protein {ECO:0000313|EMBL:AFK36063.1} Medicago truncatula (Barrel medic) (Medicago tribuloides). AFK36063.1

I3S721 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:ACJ85483.1} Medicago truncatula (Barrel medic) (Medicago tribuloides). ACJ85483.1

B7FL49 [T]

Sid 478 3.1.2.12
Mus musculus (Mouse). AAH46766.2
BAA84693.1
BAB25090.1
BAB27115.1
BAB32330.1
BAC37555.1
BAC40154.1
NP_058599.1
Q9R0P3 [P]
Q9R0P3.1

cDNA clone:J023061H06, full insert sequence {ECO:0000313|EMBL:BAG92046.1} Oryza sativa subsp. japonica (Rice). BAD87610.1
BAF07265.1
BAG87137.1
BAG92046.1
NP_001045351.1
Q5JLP6 [T]

cDNA clone:002-183-E01, full insert sequence {ECO:0000313|EMBL:BAG99267.1} Oryza sativa subsp. japonica (Rice). BAG99267.1

B7F3S0 [T]

Esterase D/formylglutathione hydrolase {ECO:0000313|EMBL:ACR54133.1} Palaemonetes varians (Atlantic ditch shrimp) (Palaemon varians). ACR54133.1

D7F2N3 [T]

Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000009965} Pan troglodytes (Chimpanzee).
XP_009425209.1
XP_509772.1
H2Q7J5 [T]

S-formylglutathione hydrolase {ECO:0000313|EMBL:BAM18637.1} Papilio xuthus (Asian swallowtail butterfly). BAM18637.1

I4DL47 [T]

Putative carbohydrate esterase family 1 protein {ECO:0000313|EMBL:AFN02839.1} Phakopsora pachyrhizi (Asian soybean rust disease fungus). AFN02839.1

I6TU74 [T]

Uncharacterized protein {ECO:0000313|EMBL:ESW17573.1} Phaseolus vulgaris (Kidney bean) (French bean). AGV54444.1
ESW17573.1
XP_007145579.1
T2DNF5 [T]

Putative uncharacterized protein {ECO:0000313|EMBL:ABK22177.1} Picea sitchensis (Sitka spruce) (Pinus sitchensis). ABK22177.1

A9NNG6 [T]

Putative esterase D family protein {ECO:0000313|EMBL:EEE91536.1} Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa). ABK95198.1
ABK95429.1
EEE91536.1
XP_002308013.1
A9PFP5 [T]

Esterase D 3.1.2.12
Rattus norvegicus (Rat). AAI58791.1
EDM02281.1
NP_001099521.1
NP_001257794.1
NP_001257795.1
B0BNE5 [P]
B0BNE5.1

S-formylglutathione hydrolase 3.1.2.12
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). AHY78937.1
AJP39638.1
AJR55222.1
AJR55532.1
AJR55860.1
AJR56189.1
AJR56514.1
AJR56841.1
AJR57169.1
AJR57498.1
AJR57826.1
AJR58154.1
AJR58480.1
AJR58806.1
AJR59459.1
AJR59789.1
AJR60446.1
AJR60774.1
AJR61098.1
AJR61424.1
AJR63386.1
AJR64931.1
AJR65259.1
AJR65590.1
AJR66893.1
AJR67221.1
AJR67551.1
AJR67845.1
AJR68173.1
AJR68490.1
AJR68815.1
AJR70445.1
AJR72403.1
AJR72730.1
AJR73059.1
AJR73722.1
AJR74034.1
AJR74352.1
AJR75018.1
AJV40315.1
AJV40640.1
AJV41297.1
AJV41945.1
AJV42272.1
AJV42598.1
AJV43910.1
CAA61307.1
CAA84054.1
CAA89359.1
CAY80711.2
DAA08731.1
EDV12696.1
EDZ71277.1
EEU06753.1
EGA78329.1
EGA82230.1
EGA86279.1
EHN06489.1
EIW09463.1
EWG90334.1
EWG95063.1
EWH17808.1
NP_012467.1
A0A023ZL37
A0A024XMD7
A0A024Y179
B3LQ43
B5VLB1
C7GR45
C8ZBE5
E7KQC3
E7LW85
E7QGJ3
H0GIC4
N1P0U8
P40363 [P]
P40363.1
W7RD33
1PV1
3C6B
4FLM
4FOL
Esterase D 3.1.2.12
Sus scrofa (Pig). AAG17630.1
BAA92850.1
BAB11922.1
NP_999225.1
XP_005668471.1
Q9GJT2 [T]
Q9GJT2.1

Esterase D {ECO:0000313|EMBL:ABF56174.1} Theobroma cacao (Cacao) (Cocoa). ABF56174.1

Q1HPB2 [T]

Putative carbohydrate esterase family 1 {ECO:0000313|EMBL:CCA94941.1} uncultured eukaryote. CCA94941.1

G8YZT6 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38306.1} uncultured fungus. ADJ38306.1

D9CIC0 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38307.1} uncultured fungus. ADJ38307.1

D9CIC1 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38300.1} uncultured fungus. ADJ38300.1

D9CIB4 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38303.1} uncultured fungus. ADJ38303.1

D9CIB7 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38304.1} uncultured fungus. ADJ38304.1

D9CIB8 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38305.1} uncultured fungus. ADJ38305.1

D9CIB9 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38302.1} uncultured fungus. ADJ38302.1

D9CIB6 [T]

Carbohydrate esterase family 1 {ECO:0000313|EMBL:ADJ38301.1} uncultured fungus. ADJ38301.1

D9CIB5 [T]

Uncharacterized protein {ECO:0000313|EMBL:ACR37690.1, ECO:0000313|EnsemblPlants:GRMZM2G046558_P02} Zea mays (Maize). ACG31468.1
ACR37690.1
AFW84000.1
NP_001148438.1
B6T2Y5 [T]

Uncharacterized protein {ECO:0000313|EMBL:ACN36841.1} Zea mays (Maize). ACN36841.1

C0PNS5 [T]